Adenocarcinoma of the Esophagus: Risk factors and prevention

Elisabeth I. Heath, Paul John Limburg, Ernest T. Hawk, Arlene A. Forastiere

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Esophageal cancer, with an estimated number of 12,300 new cases in the year 2000, is relatively uncommon in the United States but produces a high number of annual deaths, estimated at 12,100. Moreover, the incidence of the adenocarcinoma histologic type of esophageal cancer has been rising over the past two decades. Identification of risk factors could lead to primary prevention, as well as earlier diagnosis, treatment, and increased survival. Multiple risk factors are associated with the development of esophageal adenocarcinoma. These include Barrett's esophagus, acid peptic disorders, motor disorders of the esophagus, other malignancies, medications, environmental exposures, diet, and nutrition. However, no one particular risk factor is responsible for the rising incidence of esophageal cancer. Several preventive strategies are under investigation using such agents as non-steroidal anti-inflammatory drugs (NSAIDs), selenium, alpha-difluoromethylornithine (DFMO), and retinoids. As we gain more insight into the biology of this disease, other risk factors will hopefully be identified that will enable us to develop effective prevention strategies and, thus, reverse the current rising incidence of esophageal carcinoma.

Original languageEnglish (US)
Pages (from-to)507-514
Number of pages8
JournalOncology
Volume14
Issue number4
StatePublished - 2000
Externally publishedYes

Fingerprint

Esophageal Neoplasms
Incidence
Adenocarcinoma
Eflornithine
Barrett Esophagus
Retinoids
Environmental Exposure
Non-Steroidal Anti-Inflammatory Agents
Primary Prevention
Selenium
Esophagus
Early Diagnosis
Digestion
Diet
Carcinoma
Acids
Adenocarcinoma Of Esophagus
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Heath, E. I., Limburg, P. J., Hawk, E. T., & Forastiere, A. A. (2000). Adenocarcinoma of the Esophagus: Risk factors and prevention. Oncology, 14(4), 507-514.

Adenocarcinoma of the Esophagus : Risk factors and prevention. / Heath, Elisabeth I.; Limburg, Paul John; Hawk, Ernest T.; Forastiere, Arlene A.

In: Oncology, Vol. 14, No. 4, 2000, p. 507-514.

Research output: Contribution to journalArticle

Heath, EI, Limburg, PJ, Hawk, ET & Forastiere, AA 2000, 'Adenocarcinoma of the Esophagus: Risk factors and prevention', Oncology, vol. 14, no. 4, pp. 507-514.
Heath EI, Limburg PJ, Hawk ET, Forastiere AA. Adenocarcinoma of the Esophagus: Risk factors and prevention. Oncology. 2000;14(4):507-514.
Heath, Elisabeth I. ; Limburg, Paul John ; Hawk, Ernest T. ; Forastiere, Arlene A. / Adenocarcinoma of the Esophagus : Risk factors and prevention. In: Oncology. 2000 ; Vol. 14, No. 4. pp. 507-514.
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