Adaptation in the chemotactic guidance of nerve growth cones

Guo Li Ming, Scott T. Wong, John R Henley, Xiao Bing Yuan, Hong Jun Song, Nicholas C. Spitzer, Mu Ming Poo

Research output: Contribution to journalArticle

331 Citations (Scopus)

Abstract

Pathfinding by growing axons in the developing nervous system may be guided by gradients of extracellular guidance factors. Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration, undergoing consecutive phases of desensitization and resensitization in the presence of increasing basal concentrations of the guidance factor netrin-1 or brain-derived neurotrophic factor. The desensitization is specific to the guidance factor and is accompanied by a reduction of Ca2+ signalling, whereas resensitization requires activation of mitogen-associated protein kinase and local protein synthesis. Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis.

Original languageEnglish (US)
Pages (from-to)411-418
Number of pages8
JournalNature
Volume417
Issue number6887
DOIs
StatePublished - May 23 2002
Externally publishedYes

Fingerprint

Growth Cones
Chemotaxis
Psychological Adaptation
Brain-Derived Neurotrophic Factor
Xenopus
Mitogens
Protein Kinases
Nervous System
Neurons
Proteins
Psychologic Desensitization
Axon Guidance
netrin-1

ASJC Scopus subject areas

  • General

Cite this

Ming, G. L., Wong, S. T., Henley, J. R., Yuan, X. B., Song, H. J., Spitzer, N. C., & Poo, M. M. (2002). Adaptation in the chemotactic guidance of nerve growth cones. Nature, 417(6887), 411-418. https://doi.org/10.1038/nature745

Adaptation in the chemotactic guidance of nerve growth cones. / Ming, Guo Li; Wong, Scott T.; Henley, John R; Yuan, Xiao Bing; Song, Hong Jun; Spitzer, Nicholas C.; Poo, Mu Ming.

In: Nature, Vol. 417, No. 6887, 23.05.2002, p. 411-418.

Research output: Contribution to journalArticle

Ming, GL, Wong, ST, Henley, JR, Yuan, XB, Song, HJ, Spitzer, NC & Poo, MM 2002, 'Adaptation in the chemotactic guidance of nerve growth cones', Nature, vol. 417, no. 6887, pp. 411-418. https://doi.org/10.1038/nature745
Ming GL, Wong ST, Henley JR, Yuan XB, Song HJ, Spitzer NC et al. Adaptation in the chemotactic guidance of nerve growth cones. Nature. 2002 May 23;417(6887):411-418. https://doi.org/10.1038/nature745
Ming, Guo Li ; Wong, Scott T. ; Henley, John R ; Yuan, Xiao Bing ; Song, Hong Jun ; Spitzer, Nicholas C. ; Poo, Mu Ming. / Adaptation in the chemotactic guidance of nerve growth cones. In: Nature. 2002 ; Vol. 417, No. 6887. pp. 411-418.
@article{e323fc78410144149698d77b5e0a39b8,
title = "Adaptation in the chemotactic guidance of nerve growth cones",
abstract = "Pathfinding by growing axons in the developing nervous system may be guided by gradients of extracellular guidance factors. Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration, undergoing consecutive phases of desensitization and resensitization in the presence of increasing basal concentrations of the guidance factor netrin-1 or brain-derived neurotrophic factor. The desensitization is specific to the guidance factor and is accompanied by a reduction of Ca2+ signalling, whereas resensitization requires activation of mitogen-associated protein kinase and local protein synthesis. Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis.",
author = "Ming, {Guo Li} and Wong, {Scott T.} and Henley, {John R} and Yuan, {Xiao Bing} and Song, {Hong Jun} and Spitzer, {Nicholas C.} and Poo, {Mu Ming}",
year = "2002",
month = "5",
day = "23",
doi = "10.1038/nature745",
language = "English (US)",
volume = "417",
pages = "411--418",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6887",

}

TY - JOUR

T1 - Adaptation in the chemotactic guidance of nerve growth cones

AU - Ming, Guo Li

AU - Wong, Scott T.

AU - Henley, John R

AU - Yuan, Xiao Bing

AU - Song, Hong Jun

AU - Spitzer, Nicholas C.

AU - Poo, Mu Ming

PY - 2002/5/23

Y1 - 2002/5/23

N2 - Pathfinding by growing axons in the developing nervous system may be guided by gradients of extracellular guidance factors. Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration, undergoing consecutive phases of desensitization and resensitization in the presence of increasing basal concentrations of the guidance factor netrin-1 or brain-derived neurotrophic factor. The desensitization is specific to the guidance factor and is accompanied by a reduction of Ca2+ signalling, whereas resensitization requires activation of mitogen-associated protein kinase and local protein synthesis. Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis.

AB - Pathfinding by growing axons in the developing nervous system may be guided by gradients of extracellular guidance factors. Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation during chemotactic migration, undergoing consecutive phases of desensitization and resensitization in the presence of increasing basal concentrations of the guidance factor netrin-1 or brain-derived neurotrophic factor. The desensitization is specific to the guidance factor and is accompanied by a reduction of Ca2+ signalling, whereas resensitization requires activation of mitogen-associated protein kinase and local protein synthesis. Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis.

UR - http://www.scopus.com/inward/record.url?scp=0037161816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037161816&partnerID=8YFLogxK

U2 - 10.1038/nature745

DO - 10.1038/nature745

M3 - Article

C2 - 11986620

AN - SCOPUS:0037161816

VL - 417

SP - 411

EP - 418

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6887

ER -