Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis

Adi Diab, Lynette Zickl, Omar Abdel-Wahab, Suresh Jhanwar, Manjit A. Gulam, Katherine S. Panageas, Jay P. Patel, Joseph Jurcic, Peter Maslak, Elisabeth Paietta, James K. Mangan, Martin Carroll, Hugo F. Fernandez, Julie Teruya-Feldstein, Selina M. Luger, Dan Douer, Mark R. Litzow, Hillard M. Lazarus, Jacob M. Rowe, Ross L. LevineMartin S. Tallman

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, cytomorphologic, immunophenotypic and cytogenetic features. Half of the patients had extramedullary disease, most commonly leukemia cutis, which often preceded bone marrow involvement and six had therapy-related AML. Patients with t(8;16) AML commonly present with clinical and pathological features that mimic APL, with promyelocytes and promyeloblast-like cells and coagulopathy in most patients. Several patients also presented with marrow histiocytes with hemophagocytosis and erythrophagocytosis. Comprehensive molecular analysis for co-occurring genetic alterations revealed a somatic mutation in RUNX1 in 1 of 6 t(8;16) patients with no known AML mutation in the remaining five t(8;16) patients. This suggests that the t(8;16) translocation could be sufficient to induce hematopoietic cell transformation to AML without acquiring other genetic alteration. These data further support classifying t(8;16) AML as a clinically and molecularly defined subtype of AML marked by characteristic clinical and cytomorphologic features that mimic APL, and is associated with very poor survival.

Original languageEnglish (US)
Pages (from-to)32-36
Number of pages5
JournalLeukemia Research
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • AML
  • APL
  • Leukemia
  • T(8;16)
  • Therapy-related AML

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Diab, A., Zickl, L., Abdel-Wahab, O., Jhanwar, S., Gulam, M. A., Panageas, K. S., Patel, J. P., Jurcic, J., Maslak, P., Paietta, E., Mangan, J. K., Carroll, M., Fernandez, H. F., Teruya-Feldstein, J., Luger, S. M., Douer, D., Litzow, M. R., Lazarus, H. M., Rowe, J. M., ... Tallman, M. S. (2013). Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis. Leukemia Research, 37(1), 32-36. https://doi.org/10.1016/j.leukres.2012.08.025