Acute leukemia during pregnancy: A single institutional experience with 17 cases

L. J.S. Greenlund, L. Letendre, A. Tefferi

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

We reviewed the medical records of 17 consecutive patients with concomitant acute leukemia and pregnancy seen at our institution over a 37-year period. Fifteen cases each were either newly diagnosed or classified as acute myeloid leukemia (AML). Seven diagnoses (41%) occurred in the first, 7 (41%) in the second, and 3 (18%) in the third trimester. In general, nine patients received chemotherapy while pregnant-eight in the second trimester and one in the third. The overall complete remission rate among the 13 patients with newly diagnosed AML was 69%, compared with 86% in those who were pregnant during chemotherapy. Long-term survival was documented in five of the nine complete responders. Three of four patients who elected to delay treatment until after delivery died within days of starting chemotherapy. Unintentional fetal loss occurred in four patients (29%), including two without exposure to chemotherapy. There were no instances of congenital malformation. The results from the current study confirm that pregnancy per se may not affect the outcome of chemotherapy in AML. In addition, it is suggested that treatment delays may compromise maternal outcome without improving pregnancy outcome.

Original languageEnglish (US)
Pages (from-to)571-577
Number of pages7
JournalLeukemia and Lymphoma
Volume41
Issue number5-6
DOIs
StatePublished - Jan 1 2001

Keywords

  • Acute myeloid leukemia
  • Chemotherapy
  • Pregnancy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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