Acute inescapable stress alleviates fear extinction recall deficits caused by serotonin transporter abolishment

Pieter Schipper, Marloes J.A.G. Henckens, Dora Lopresto, Tamas Kozicz, Judith R. Homberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Life stress increases risk for developing post-traumatic stress disorder (PTSD), and more prominently so in short-allele carriers of the serotonin transporter linked polymorphic region (5-HTTLPR). Serotonin transporter knockout (5-HTT−/−) rats show compromised extinction (recall) of conditioned fear, which might mediate the increased risk for PTSD and reduce the therapeutic efficacy of exposure therapy. Here, we assessed whether acute inescapable stress (IS) differentially affects fear extinction and extinction recall in 5-HTT−/− rats and wildtype controls. Surprisingly, IS experience improved fear extinction recall in 5-HTT−/− rats to the level of wildtype animals, while wildtypes were unaffected by this IS. Thus, whereas 5-HTT−/− rats evidently were more responsive to the stressor, the behavioral consequences presented themselves as adaptive.

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalBehavioural Brain Research
Volume346
DOIs
StatePublished - Jul 2 2018
Externally publishedYes

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Fear
Post-Traumatic Stress Disorders
Implosive Therapy
Psychological Stress
Alleles
Psychological Extinction
Therapeutics

Keywords

  • 5-HTTLPR
  • Fear
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Acute inescapable stress alleviates fear extinction recall deficits caused by serotonin transporter abolishment. / Schipper, Pieter; Henckens, Marloes J.A.G.; Lopresto, Dora; Kozicz, Tamas; Homberg, Judith R.

In: Behavioural Brain Research, Vol. 346, 02.07.2018, p. 16-20.

Research output: Contribution to journalArticle

Schipper, Pieter ; Henckens, Marloes J.A.G. ; Lopresto, Dora ; Kozicz, Tamas ; Homberg, Judith R. / Acute inescapable stress alleviates fear extinction recall deficits caused by serotonin transporter abolishment. In: Behavioural Brain Research. 2018 ; Vol. 346. pp. 16-20.
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