Acute branch occlusion after Pipeline embolization of intracranial aneurysms

Rishi R. Lall, Emanuela Crobeddu, Giuseppe Lanzino, Harry J. Cloft, David F Kallmes

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Flow-diverters are used in the treatment of large and complex intracranial aneurysms. One major concern with this concept is the potential for compromise of side branches and perforators covered by the device. We describe three patients treated with the Pipeline embolization device (PED; ev3 Endovascular, Plymouth, MN, USA) who developed immediate compromise of flow into an eloquent side branch covered by the device. Three patients, two with giant posterior circulation aneurysms and one with recurrence of a previously clipped and subsequently coiled middle cerebral artery aneurysm, were each treated by placement of a single PED. Shortly after placement of the devices, despite adequate antiplatelet and anticoagulation regimens, partial or complete occlusion of a major side branch occurred. In all three patients, the occlusion was promptly reversed with intra-arterial administration of abciximab with no clinical sequelae. These cases are concerning because branch occlusion occurred even in the setting of patients appropriately premedicated with dual antiplatelet therapy and in whom genetic testing suggested clopidogrel responsiveness. Close monitoring of patients treated with these devices is critical to establish the frequency of this and other unanticipated complications.

Original languageEnglish (US)
Pages (from-to)668-672
Number of pages5
JournalJournal of Clinical Neuroscience
Volume21
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Intracranial Aneurysm
Equipment and Supplies
clopidogrel
Genetic Testing
Physiologic Monitoring
Aneurysm
Recurrence
Therapeutics

Keywords

  • Abciximab
  • Aneurysm
  • Embolization
  • Flow diversion
  • PED
  • Pipeline
  • Stent

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

Cite this

Acute branch occlusion after Pipeline embolization of intracranial aneurysms. / Lall, Rishi R.; Crobeddu, Emanuela; Lanzino, Giuseppe; Cloft, Harry J.; Kallmes, David F.

In: Journal of Clinical Neuroscience, Vol. 21, No. 4, 2014, p. 668-672.

Research output: Contribution to journalArticle

Lall, Rishi R. ; Crobeddu, Emanuela ; Lanzino, Giuseppe ; Cloft, Harry J. ; Kallmes, David F. / Acute branch occlusion after Pipeline embolization of intracranial aneurysms. In: Journal of Clinical Neuroscience. 2014 ; Vol. 21, No. 4. pp. 668-672.
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