Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

Ee Hwa Kim; Mi Hyeon Jang; Min Chul Shin; Baek Vin Lim; Hyun Bae Kim; Youn Jung Kim; Joo Ho Chung; Chang Ju Kim

doi:10.1016/S0304-3940(02)00372-5

Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

Ee Hwa Kim, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Hyun Bae Kim, Youn Jung Kim, Joo Ho Chung, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.

Original language	English (US)
Pages (from-to)	33-36
Number of pages	4
Journal	Neuroscience Letters
Volume	327
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00372-5
State	Published - Jul 12 2002

Keywords

Acupuncture
Cell proliferation
Dentate gyrus
Diabetes
Neuropeptide Y
Streptozotocin

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)00372-5

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title = "Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats",

abstract = "In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.",

keywords = "Acupuncture, Cell proliferation, Dentate gyrus, Diabetes, Neuropeptide Y, Streptozotocin",

author = "Kim, {Ee Hwa} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lim, {Baek Vin} and Kim, {Hyun Bae} and Kim, {Youn Jung} and Chung, {Joo Ho} and Kim, {Chang Ju}",

note = "Funding Information: This work was supported by grant No. 2001-2-20600-001-2 from the basic research program of the Korea Science & Engineering Foundation.",

year = "2002",

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doi = "10.1016/S0304-3940(02)00372-5",

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T1 - Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

AU - Kim, Ee Hwa

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lim, Baek Vin

AU - Kim, Hyun Bae

AU - Kim, Youn Jung

AU - Chung, Joo Ho

AU - Kim, Chang Ju

N1 - Funding Information: This work was supported by grant No. 2001-2-20600-001-2 from the basic research program of the Korea Science & Engineering Foundation.

PY - 2002/7/12

Y1 - 2002/7/12

N2 - In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.

AB - In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.

KW - Acupuncture

KW - Cell proliferation

KW - Dentate gyrus

KW - Diabetes

KW - Neuropeptide Y

KW - Streptozotocin

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Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

Abstract

Keywords

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