Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

Ee Hwa Kim, Mi-Hyeon D Jang, Min Chul Shin, Baek Vin Lim, Hyun Bae Kim, Youn Jung Kim, Joo Ho Chung, Chang Ju Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume327
Issue number1
DOIs
StatePublished - Jul 12 2002
Externally publishedYes

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Experimental Diabetes Mellitus
Neuropeptide Y
Dentate Gyrus
Acupuncture
Streptozocin
Cell Proliferation
Acupuncture Points
Control Groups
Bromodeoxyuridine
Sprague Dawley Rats
Cell Count

Keywords

  • Acupuncture
  • Cell proliferation
  • Dentate gyrus
  • Diabetes
  • Neuropeptide Y
  • Streptozotocin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats. / Kim, Ee Hwa; Jang, Mi-Hyeon D; Shin, Min Chul; Lim, Baek Vin; Kim, Hyun Bae; Kim, Youn Jung; Chung, Joo Ho; Kim, Chang Ju.

In: Neuroscience Letters, Vol. 327, No. 1, 12.07.2002, p. 33-36.

Research output: Contribution to journalArticle

Kim, Ee Hwa ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Lim, Baek Vin ; Kim, Hyun Bae ; Kim, Youn Jung ; Chung, Joo Ho ; Kim, Chang Ju. / Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats. In: Neuroscience Letters. 2002 ; Vol. 327, No. 1. pp. 33-36.
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