Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats

Ee Hwa Kim, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Hyun Bae Kim, Youn Jung Kim, Joo Ho Chung, Chang Ju Kim

Research output: Contribution to journalArticle

31 Scopus citations


In this study, effects of acupuncture at Zusanli acupoint on cell proliferation and expression of neuropeptide Y (NPY) in the dentate gyrus (DG) of streptozotocin-induced diabetic rats were investigated. Sprague-Dawley rats were divided into six groups: the control group, the non-diabetic and Zusanli-acupunctured group, the non-diabetic and non-acupoint-acupunctured group, the streptozotocin-induced-diabetes group, the streptozotocin-induced-diabetes and Zusanli-acupunctured group, and the streptozotocin-induced-diabetes and non-acupoint-acupunctured group. In the streptozotocin-induced diabetes group, the mean 5-bromo-2′-deoxyuridine-positive and NPY-positive cell counts in the DG were significantly decreased compared to the control group. Stimulation of the Zusanli resulted in increased cell proliferation and neuropeptide Y levels in the diabetic group. In the present results, it can be suggested that acupuncture may affect cell proliferation in the DG of streptozotocin-induced diabetic rats by regulating neuropeptide Y expression.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - Jul 12 2002



  • Acupuncture
  • Cell proliferation
  • Dentate gyrus
  • Diabetes
  • Neuropeptide Y
  • Streptozotocin

ASJC Scopus subject areas

  • Neuroscience(all)

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