Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Ikuo Nakamura, Maite G. Fernandez-Barrena, Maria C. Ortiz-Ruiz, Luciana L. Almada, Chunling Hu, Sherine F. Elsawa, Lisa D. Mills, Paola A. Romecin, Kadra H. Gulaid, Catherine D. Moser, Jing Jing Han, Anne Vrabel, Eric A. Hanse, Nicholas A. Akogyeram, Jeffrey H. Albrecht, Satdarshan P.S. Monga, Schuyler O. Sanderson, Jesus Prieto, Lewis R. Roberts, Martin E. Fernandez-Zapico

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis.

Original languageEnglish (US)
Pages (from-to)21389-21398
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Nakamura, I., Fernandez-Barrena, M. G., Ortiz-Ruiz, M. C., Almada, L. L., Hu, C., Elsawa, S. F., Mills, L. D., Romecin, P. A., Gulaid, K. H., Moser, C. D., Han, J. J., Vrabel, A., Hanse, E. A., Akogyeram, N. A., Albrecht, J. H., Monga, S. P. S., Sanderson, S. O., Prieto, J., Roberts, L. R., & Fernandez-Zapico, M. E. (2013). Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. Journal of Biological Chemistry, 288(29), 21389-21398. https://doi.org/10.1074/jbc.M112.443440