Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Ikuo Nakamura, Maite G. Fernandez-Barrena, Maria C. Ortiz-Ruiz, Luciana L. Almada, Chunling Hu, Sherine F. Elsawa, Lisa D. Mills, Paola A. Romecin, Kadra H. Gulaid, Catherine D. Moser, Jing Jing Han, Anne Vrabel, Eric A. Hanse, Nicholas A. Akogyeram, Jeffrey H. Albrecht, Satdarshan P S Monga, Schuyler O. Sanderson, Jesus Prieto, Lewis Rowland Roberts, Martin E Fernandez-Zapico

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis.

Original languageEnglish (US)
Pages (from-to)21389-21398
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013

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Tissue regeneration
Regeneration
Transcription Factors
Chemical activation
Sulfatases
Cell proliferation
Organogenesis
Ligands
Cell Proliferation
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. / Nakamura, Ikuo; Fernandez-Barrena, Maite G.; Ortiz-Ruiz, Maria C.; Almada, Luciana L.; Hu, Chunling; Elsawa, Sherine F.; Mills, Lisa D.; Romecin, Paola A.; Gulaid, Kadra H.; Moser, Catherine D.; Han, Jing Jing; Vrabel, Anne; Hanse, Eric A.; Akogyeram, Nicholas A.; Albrecht, Jeffrey H.; Monga, Satdarshan P S; Sanderson, Schuyler O.; Prieto, Jesus; Roberts, Lewis Rowland; Fernandez-Zapico, Martin E.

In: Journal of Biological Chemistry, Vol. 288, No. 29, 19.07.2013, p. 21389-21398.

Research output: Contribution to journalArticle

Nakamura, I, Fernandez-Barrena, MG, Ortiz-Ruiz, MC, Almada, LL, Hu, C, Elsawa, SF, Mills, LD, Romecin, PA, Gulaid, KH, Moser, CD, Han, JJ, Vrabel, A, Hanse, EA, Akogyeram, NA, Albrecht, JH, Monga, SPS, Sanderson, SO, Prieto, J, Roberts, LR & Fernandez-Zapico, ME 2013, 'Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration', Journal of Biological Chemistry, vol. 288, no. 29, pp. 21389-21398. https://doi.org/10.1074/jbc.M112.443440
Nakamura, Ikuo ; Fernandez-Barrena, Maite G. ; Ortiz-Ruiz, Maria C. ; Almada, Luciana L. ; Hu, Chunling ; Elsawa, Sherine F. ; Mills, Lisa D. ; Romecin, Paola A. ; Gulaid, Kadra H. ; Moser, Catherine D. ; Han, Jing Jing ; Vrabel, Anne ; Hanse, Eric A. ; Akogyeram, Nicholas A. ; Albrecht, Jeffrey H. ; Monga, Satdarshan P S ; Sanderson, Schuyler O. ; Prieto, Jesus ; Roberts, Lewis Rowland ; Fernandez-Zapico, Martin E. / Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 29. pp. 21389-21398.
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AU - Almada, Luciana L.

AU - Hu, Chunling

AU - Elsawa, Sherine F.

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AU - Albrecht, Jeffrey H.

AU - Monga, Satdarshan P S

AU - Sanderson, Schuyler O.

AU - Prieto, Jesus

AU - Roberts, Lewis Rowland

AU - Fernandez-Zapico, Martin E

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