ACTION SPECTRA OF THE ANTILEUKEMIC and ANTIVIRAL ACTIVITIES OF MEROCYANINE 540

J. M. O'Brien; R. J. Singh; J. B. Feix; B. Kalyanaraman; F. Sieber

doi:10.1111/j.1751-1097.1991.tb02101.x

ACTION SPECTRA OF THE ANTILEUKEMIC and ANTIVIRAL ACTIVITIES OF MEROCYANINE 540

J. M. O'Brien, R. J. Singh, J. B. Feix, B. Kalyanaraman, F. Sieber

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane‐bound dye monomer, and by implication, the action spectrum of ¹O₂ generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane‐bound monomer and at least in part mediated by ¹O₂.

Original language	English (US)
Pages (from-to)	851-854
Number of pages	4
Journal	Photochemistry and Photobiology
Volume	54
Issue number	5
DOIs	https://doi.org/10.1111/j.1751-1097.1991.tb02101.x
State	Published - Nov 1991

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry

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10.1111/j.1751-1097.1991.tb02101.x

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abstract = "Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane‐bound dye monomer, and by implication, the action spectrum of 1O2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane‐bound monomer and at least in part mediated by 1O2.",

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AU - Singh, R. J.

AU - Feix, J. B.

AU - Kalyanaraman, B.

AU - Sieber, F.

PY - 1991/11

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N2 - Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane‐bound dye monomer, and by implication, the action spectrum of 1O2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane‐bound monomer and at least in part mediated by 1O2.

AB - Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane‐bound dye monomer, and by implication, the action spectrum of 1O2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane‐bound monomer and at least in part mediated by 1O2.

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ACTION SPECTRA OF THE ANTILEUKEMIC and ANTIVIRAL ACTIVITIES OF MEROCYANINE 540

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