ACTION SPECTRA OF THE ANTILEUKEMIC and ANTIVIRAL ACTIVITIES OF MEROCYANINE 540

J. M. O'Brien, R. J. Singh, J. B. Feix, B. Kalyanaraman, F. Sieber

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane‐bound dye monomer, and by implication, the action spectrum of 1O2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane‐bound monomer and at least in part mediated by 1O2.

Original languageEnglish (US)
Pages (from-to)851-854
Number of pages4
JournalPhotochemistry and Photobiology
Volume54
Issue number5
DOIs
StatePublished - Nov 1991

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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