Abstract
Subiculum is the primary output area of the hippocampus and serves as a key relay center in the process of memory formation and retrieval. A majority of subicular pyramidal neurons communicate via bursts of action potentials, a mode of signaling that may enhance the fidelity of information transfer and synaptic plasticity or contribute to epilepsy when unchecked. In the present study, we show that a Ca2+ tail current drives bursting in subicular pyramidal neurons. An action potential activates voltage-activated Ca2+ channels, which deactivate slowly enough during action potential repolarization to produce an afterdepolarization that triggers subsequent action potentials in the burst. The Ca2+ channels underlying bursting are located primarily near the soma, and the amplitude of Ca2+ tail currents correlates with the strength of bursting across cells. Multiple channel subtypes contribute to Ca2+ tail current, but the need for an action potential to produce the slow depolarization suggests a central role for high-voltage-activated Ca2+ channels in subicular neuron bursting.
Original language | English (US) |
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Pages (from-to) | 3312-3321 |
Number of pages | 10 |
Journal | Journal of Neuroscience |
Volume | 21 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2001 |
Keywords
- Bursting mechanism
- Ca currents
- HVA channels
- Hippocampus
- Patch clamp
- Subiculum
ASJC Scopus subject areas
- General Neuroscience