TY - JOUR
T1 - Acrylamide Neuropathy in the Rat
T2 - Effects on Energy Metabolism in Sciatic Nerve
AU - BRIMIJOIN, W. STEVEN
AU - HAMMOND, PAMELA I.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Energy metabolism was examined in rat sciatic nerve before and after induction of neuropathy by treatment with acrylamide monomer. The in vivo activities of two glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase and nerve-specific enolase, were resistant to acrylamide. The levels of adenosine 5′-triphosphate and creatine phosphate were also unaffected by acrylamide after either short-term or long-term treatment. The turnover of high-energy phosphate was somewhat reduced in the nerves of severely intoxicated animals. These findings cast doubt on the hypothesis that acrylamide neuropathy begins with an attack on the means of generating metabolic energy, although the eventual failure of one or more energy-consuming processes in peripheral nerve remains likely.
AB - Energy metabolism was examined in rat sciatic nerve before and after induction of neuropathy by treatment with acrylamide monomer. The in vivo activities of two glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase and nerve-specific enolase, were resistant to acrylamide. The levels of adenosine 5′-triphosphate and creatine phosphate were also unaffected by acrylamide after either short-term or long-term treatment. The turnover of high-energy phosphate was somewhat reduced in the nerves of severely intoxicated animals. These findings cast doubt on the hypothesis that acrylamide neuropathy begins with an attack on the means of generating metabolic energy, although the eventual failure of one or more energy-consuming processes in peripheral nerve remains likely.
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U2 - 10.1016/S0025-6196(12)65275-6
DO - 10.1016/S0025-6196(12)65275-6
M3 - Article
C2 - 2981375
AN - SCOPUS:0021924344
SN - 0025-6196
VL - 60
SP - 3
EP - 8
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 1
ER -