ACR appropriateness criteria® follow-up and retreatment of brain metastases

Samir H. Patel, Jared R. Robbins, Elizabeth M. Gore, Jeffrey D. Bradley, Laurie E. Gaspar, Isabelle Germano, Paiman Ghafoori, Mark A. Henderson, Stephen T. Lutz, Michael W. McDermott, Roy A. Patchell, H. Ian Robins, Andrew D. Vassil, Franz J. Wippold, Gregory M. Videtic

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Multiple options for retreatment are available, which include whole-brain radiation therapy, stereotactic radiosurgery, surgery, chemotherapy, and supportive care. Size, number, timing, location, histology, performance status, and extracranial disease status all need to be carefully considered when choosing a treatment modality. There are no randomized trials examining the retreatment of brain metastases. Repeat whole-brain radiation has been examined in a single-institution experience, showing the potential for clinical responses in selected patients. Local control rates as high as 91% using stereotactic radiosurgery for relapses after whole-brain radiation are reported. Surgery can be indicated in progressive and/or hemorrhagic lesions causing mass effect. The role of chemotherapy in the recurrent setting is limited but some agents may have activity on the basis of experiences on a smaller scale. Supportive care continues to be an important option, especially in those with a poor prognosis. Follow-up for brain metastases patients is discussed, examining the modality, frequency of imaging, and imaging options in differentiating treatment effect from recurrence. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of the current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume35
Issue number3
DOIs
StatePublished - Jun 1 2012

Keywords

  • appropriateness criteria
  • brain metastases
  • radiation therapy
  • radiosurgery
  • recurrence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Patel, S. H., Robbins, J. R., Gore, E. M., Bradley, J. D., Gaspar, L. E., Germano, I., Ghafoori, P., Henderson, M. A., Lutz, S. T., McDermott, M. W., Patchell, R. A., Robins, H. I., Vassil, A. D., Wippold, F. J., & Videtic, G. M. (2012). ACR appropriateness criteria® follow-up and retreatment of brain metastases. American Journal of Clinical Oncology: Cancer Clinical Trials, 35(3), 302-306. https://doi.org/10.1097/COC.0b013e31824be246