Acoustic navigation of intramyocardial injection needle catheter using color doppler echocardiography

Minako Katayama, Viksit Kumar, David Zarbatany, Veronica Vaitkus, David Fortuin, Mostafa Fatemi, Marek Belohlavek

Research output: Contribution to journalConference article

Abstract

Background: Drug or stem cell intramyocardial delivery has been tested using transendocardial injections navigated by fluoroscopy and NOGA electromechanical mapping system. However, the exact location of the needle tip and the injection depth within the myocardium are difficult to determine due to limitations in depicting cardiac anatomy, and muscle thickness in particular, with fluoroscopy or NOGA. The objective was to develop a prototype of an intramyocardial injection catheter that allows visual localization of the injection needle tip in the myocardium under the guidance of conventional 2D color Doppler echocardiography. Methods: An acoustically active catheter (AAC)with a retractable injection needle was constructed using a commercially available steerable sheath and piezoelectric crystals. The navigation and myocardial injection were tested in a beating heart in animal experiments. Crystals on the AAC tip and needle tip were driven by a waveform generator and produced acoustic interactions with Doppler beam. The interaction resulted in realtime color markers in echocardiography scans. Results: In all cases, both AAC catheter tip and inserted needle tip in the myocardium were visualized clearly. Green color dye was injected through the needle lumen and successful formation of a dye deposit was observed at autopsy in 15 of 20 attempts. Conclusion: The concept of acoustically active navigation of the injection needle in a beating heart is presented. Guiding the injection needle within the left ventricular myocardium has potential to provide safer intramyocardial therapeutic delivery, utilizing a conventionally available echocardiography system.

Original languageEnglish (US)
Article number8579717
JournalIEEE International Ultrasonics Symposium, IUS
Volume2018-January
DOIs
StatePublished - Jan 1 2018
Event2018 IEEE International Ultrasonics Symposium, IUS 2018 - Kobe, Japan
Duration: Oct 22 2018Oct 25 2018

Fingerprint

echocardiography
navigation
needles
injection
color
myocardium
acoustics
fluoroscopy
delivery
dyes
autopsies
piezoelectric crystals
lumens
stem cells
anatomy
muscles
sheaths
markers
crystals
animals

Keywords

  • acoustically active catheter
  • color flow Doppler
  • ultrasonographic navigation
  • ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Acoustic navigation of intramyocardial injection needle catheter using color doppler echocardiography. / Katayama, Minako; Kumar, Viksit; Zarbatany, David; Vaitkus, Veronica; Fortuin, David; Fatemi, Mostafa; Belohlavek, Marek.

In: IEEE International Ultrasonics Symposium, IUS, Vol. 2018-January, 8579717, 01.01.2018.

Research output: Contribution to journalConference article

Katayama, Minako ; Kumar, Viksit ; Zarbatany, David ; Vaitkus, Veronica ; Fortuin, David ; Fatemi, Mostafa ; Belohlavek, Marek. / Acoustic navigation of intramyocardial injection needle catheter using color doppler echocardiography. In: IEEE International Ultrasonics Symposium, IUS. 2018 ; Vol. 2018-January.
@article{a621b71a476a4983a682c3b178589f97,
title = "Acoustic navigation of intramyocardial injection needle catheter using color doppler echocardiography",
abstract = "Background: Drug or stem cell intramyocardial delivery has been tested using transendocardial injections navigated by fluoroscopy and NOGA electromechanical mapping system. However, the exact location of the needle tip and the injection depth within the myocardium are difficult to determine due to limitations in depicting cardiac anatomy, and muscle thickness in particular, with fluoroscopy or NOGA. The objective was to develop a prototype of an intramyocardial injection catheter that allows visual localization of the injection needle tip in the myocardium under the guidance of conventional 2D color Doppler echocardiography. Methods: An acoustically active catheter (AAC)with a retractable injection needle was constructed using a commercially available steerable sheath and piezoelectric crystals. The navigation and myocardial injection were tested in a beating heart in animal experiments. Crystals on the AAC tip and needle tip were driven by a waveform generator and produced acoustic interactions with Doppler beam. The interaction resulted in realtime color markers in echocardiography scans. Results: In all cases, both AAC catheter tip and inserted needle tip in the myocardium were visualized clearly. Green color dye was injected through the needle lumen and successful formation of a dye deposit was observed at autopsy in 15 of 20 attempts. Conclusion: The concept of acoustically active navigation of the injection needle in a beating heart is presented. Guiding the injection needle within the left ventricular myocardium has potential to provide safer intramyocardial therapeutic delivery, utilizing a conventionally available echocardiography system.",
keywords = "acoustically active catheter, color flow Doppler, ultrasonographic navigation, ultrasound",
author = "Minako Katayama and Viksit Kumar and David Zarbatany and Veronica Vaitkus and David Fortuin and Mostafa Fatemi and Marek Belohlavek",
year = "2018",
month = "1",
day = "1",
doi = "10.1109/ULTSYM.2018.8579717",
language = "English (US)",
volume = "2018-January",
journal = "IEEE International Ultrasonics Symposium, IUS",
issn = "1948-5719",

}

TY - JOUR

T1 - Acoustic navigation of intramyocardial injection needle catheter using color doppler echocardiography

AU - Katayama, Minako

AU - Kumar, Viksit

AU - Zarbatany, David

AU - Vaitkus, Veronica

AU - Fortuin, David

AU - Fatemi, Mostafa

AU - Belohlavek, Marek

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Drug or stem cell intramyocardial delivery has been tested using transendocardial injections navigated by fluoroscopy and NOGA electromechanical mapping system. However, the exact location of the needle tip and the injection depth within the myocardium are difficult to determine due to limitations in depicting cardiac anatomy, and muscle thickness in particular, with fluoroscopy or NOGA. The objective was to develop a prototype of an intramyocardial injection catheter that allows visual localization of the injection needle tip in the myocardium under the guidance of conventional 2D color Doppler echocardiography. Methods: An acoustically active catheter (AAC)with a retractable injection needle was constructed using a commercially available steerable sheath and piezoelectric crystals. The navigation and myocardial injection were tested in a beating heart in animal experiments. Crystals on the AAC tip and needle tip were driven by a waveform generator and produced acoustic interactions with Doppler beam. The interaction resulted in realtime color markers in echocardiography scans. Results: In all cases, both AAC catheter tip and inserted needle tip in the myocardium were visualized clearly. Green color dye was injected through the needle lumen and successful formation of a dye deposit was observed at autopsy in 15 of 20 attempts. Conclusion: The concept of acoustically active navigation of the injection needle in a beating heart is presented. Guiding the injection needle within the left ventricular myocardium has potential to provide safer intramyocardial therapeutic delivery, utilizing a conventionally available echocardiography system.

AB - Background: Drug or stem cell intramyocardial delivery has been tested using transendocardial injections navigated by fluoroscopy and NOGA electromechanical mapping system. However, the exact location of the needle tip and the injection depth within the myocardium are difficult to determine due to limitations in depicting cardiac anatomy, and muscle thickness in particular, with fluoroscopy or NOGA. The objective was to develop a prototype of an intramyocardial injection catheter that allows visual localization of the injection needle tip in the myocardium under the guidance of conventional 2D color Doppler echocardiography. Methods: An acoustically active catheter (AAC)with a retractable injection needle was constructed using a commercially available steerable sheath and piezoelectric crystals. The navigation and myocardial injection were tested in a beating heart in animal experiments. Crystals on the AAC tip and needle tip were driven by a waveform generator and produced acoustic interactions with Doppler beam. The interaction resulted in realtime color markers in echocardiography scans. Results: In all cases, both AAC catheter tip and inserted needle tip in the myocardium were visualized clearly. Green color dye was injected through the needle lumen and successful formation of a dye deposit was observed at autopsy in 15 of 20 attempts. Conclusion: The concept of acoustically active navigation of the injection needle in a beating heart is presented. Guiding the injection needle within the left ventricular myocardium has potential to provide safer intramyocardial therapeutic delivery, utilizing a conventionally available echocardiography system.

KW - acoustically active catheter

KW - color flow Doppler

KW - ultrasonographic navigation

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85062353171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062353171&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2018.8579717

DO - 10.1109/ULTSYM.2018.8579717

M3 - Conference article

VL - 2018-January

JO - IEEE International Ultrasonics Symposium, IUS

JF - IEEE International Ultrasonics Symposium, IUS

SN - 1948-5719

M1 - 8579717

ER -