ACE inhibitors

Upper respiratory symptoms

Paulette Pinargote, Denisse Guillen, Juan C. Guarderas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cough and angioedema are well-known adverse reactions of ACE inhibitors. However, other adverse effects of upper airways such as postnasal drainage, rhinitis and nasal blockage, are less frequently recognised. These might share the same pathophysiological mechanism: bradykinin accumulation. We present two patients with ACE inhibitor-induced upper respiratory symptoms that improved after the discontinuation of ACE-inhibitors and substitution with angiotensin II receptor blockers. The incidence of these adverse events is not accurately known, since these are not required to be reported, but it is estimated to be low. This presents challenges to the physician and demonstrates the importance of keeping it as a differential diagnosis. Most physicians are aware of ACE inhibitor-induced cough but not of ACE inhibitor-induced nasal blockage, rhinitis or postnasal drainage. Identifying these can avoid unnecessary diagnostic tests and inappropriate treatment.

Original languageEnglish (US)
JournalBMJ Case Reports
DOIs
StatePublished - Jul 17 2014

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Angiotensin-Converting Enzyme Inhibitors
Nasal Obstruction
Rhinitis
Cough
Drainage
Physicians
Angioedema
Angiotensin Receptor Antagonists
Bradykinin
Routine Diagnostic Tests
Differential Diagnosis
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

ACE inhibitors : Upper respiratory symptoms. / Pinargote, Paulette; Guillen, Denisse; Guarderas, Juan C.

In: BMJ Case Reports, 17.07.2014.

Research output: Contribution to journalArticle

Pinargote, Paulette ; Guillen, Denisse ; Guarderas, Juan C. / ACE inhibitors : Upper respiratory symptoms. In: BMJ Case Reports. 2014.
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