Accelerated hyperfractionation radiation therapy after lumpectomy and axillary lymph node dissection in patients with stage I or II breast cancer: Pilot study

Paula J. Schomberg, Thomas G. Shanahan, James N. Ingle, John H. Donohue, Robert R. Kuske, William C. Sternfeld, Lester Wold, Stephen S. Cha, Ivy A. Petersen, Jeffrey S. Brindle, Michelle Y. Halyard, John W. Bollinger, Roland Hawkins, Thomas M. Pisansky

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

PURPOSE: To prospectively assess tolerance to accelerated hyperfractionation radiation therapy in patients undergoing breast- conservation therapy and to exclude, with 90% confidence, a 20% or greater risk of an acute toxic reaction of at least grade 3 (severe). MATERIALS AND METHODS: Thirty-seven patients (aged 33-80 years) with evaluatable cases received 48 Gy in twice-daily 1.6-Gy fractions to the breast and regional lymph nodes (if three or more lymph nodes were involved) and a boost of 9.6 Gy in twice-daily 1.6-Gy fractions. Acute and late effects were scored by using the Radiation Therapy Oncology Group and European Organization for the Research and Treatment of Cancer radiation morbidity criteria. RESULTS: One patient developed a grade 3 acute skin toxic reaction and another grade 3 (continuous) acute edema. There have been no grade 4 (life-threatening) acute toxic reactions, local recurrences, or cancer- or treatment-related deaths. CONCLUSION: This breast-conservation accelerated hyperfractionation radiation therapy schedule is tolerable. Additional follow-up is necessary to determine long-term morbidity and cosmesis, and further study in a larger patient group is necessary to confirm efficacy.

Original languageEnglish (US)
Pages (from-to)565-569
Number of pages5
JournalRadiology
Volume202
Issue number2
DOIs
StatePublished - Feb 1997

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Keywords

  • Breast neoplasms, therapeutic radiology
  • Therapeutic radiology, postoperative
  • Treatment planning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Schomberg, P. J., Shanahan, T. G., Ingle, J. N., Donohue, J. H., Kuske, R. R., Sternfeld, W. C., Wold, L., Cha, S. S., Petersen, I. A., Brindle, J. S., Halyard, M. Y., Bollinger, J. W., Hawkins, R., & Pisansky, T. M. (1997). Accelerated hyperfractionation radiation therapy after lumpectomy and axillary lymph node dissection in patients with stage I or II breast cancer: Pilot study. Radiology, 202(2), 565-569. https://doi.org/10.1148/radiology.202.2.9015091