Accelerated filament formation from tau protein with specific FTDP-17 missense mutations

Parimala Nacharaju, Jada Lewis, Colin Easson, Samuel Yen, Jennifer Hackett, Mike Hutton, Shu Hui Yen

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Tau is the major component of the neurofibrillar tangles that are a pathological hallmark of Alzheimers' disease. The identification of missense and splicing mutations in tau associated with the inherited frontotemporal dementia and Parkinsonism linked to chromosome 17 demonstrated that tau dysfunction can cause neurodegeneration. However, the mechanism by which tau dysfunction leads to neurodegeneration remains uncertain. Here, we present evidence that frontotemporal dementia and Parkinsonism linked to chromosome 17 missense mutations, P301L, V337M and R406W, cause an accelerated aggregation of tau into filaments. These results suggest one mechanism by which these mutations can cause neurodegeneration and frontotemporal dementia and Parkinsonism linked to chromosome 17. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalFEBS Letters
Volume447
Issue number2-3
DOIs
StatePublished - Mar 26 1999

Fingerprint

tau Proteins
Frontotemporal Dementia
Chromosomes, Human, Pair 17
Missense Mutation
Chromosomes
Parkinsonian Disorders
Alzheimer Disease
Agglomeration
Mutation

Keywords

  • Frontotemporal dementia and Parkinsonism linked to chromosome 17
  • Neurodegeneration
  • Tau mutation
  • Tau polymerization
  • Tauopathy

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Nacharaju, P., Lewis, J., Easson, C., Yen, S., Hackett, J., Hutton, M., & Yen, S. H. (1999). Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. FEBS Letters, 447(2-3), 195-199. https://doi.org/10.1016/S0014-5793(99)00294-X

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. / Nacharaju, Parimala; Lewis, Jada; Easson, Colin; Yen, Samuel; Hackett, Jennifer; Hutton, Mike; Yen, Shu Hui.

In: FEBS Letters, Vol. 447, No. 2-3, 26.03.1999, p. 195-199.

Research output: Contribution to journalArticle

Nacharaju, P, Lewis, J, Easson, C, Yen, S, Hackett, J, Hutton, M & Yen, SH 1999, 'Accelerated filament formation from tau protein with specific FTDP-17 missense mutations', FEBS Letters, vol. 447, no. 2-3, pp. 195-199. https://doi.org/10.1016/S0014-5793(99)00294-X
Nacharaju P, Lewis J, Easson C, Yen S, Hackett J, Hutton M et al. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. FEBS Letters. 1999 Mar 26;447(2-3):195-199. https://doi.org/10.1016/S0014-5793(99)00294-X
Nacharaju, Parimala ; Lewis, Jada ; Easson, Colin ; Yen, Samuel ; Hackett, Jennifer ; Hutton, Mike ; Yen, Shu Hui. / Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. In: FEBS Letters. 1999 ; Vol. 447, No. 2-3. pp. 195-199.
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