Abdominal vein thrombosis in essential thrombocythemia: Prevalence, clinical correlates, and prognostic implications

Naseema Gangat, Alexandra P. Wolanskyj, Ayalew Tefferi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Among 460 consecutive patients with essential thrombocythemia (ET) seen at our institution, 19 cases (4%) of abdominal vein thrombosis (AVT) were documented either at (n = 9) or after (n = 10) diagnosis. Women (P = 0.03) and the young (P = 0.002) were preferentially affected. Accordingly, clinical comparisons were performed among three groups of female patients: those with AVT (group A; n = 17), a control group without AVT but closely matched to group A in terms of age and year of diagnosis (group B; n = 34), and all female patients without AVT (group C; n = 288). As expected from the consequences of AVT-associated portal hypertension and anticoagulant therapy, patients in group A experienced significantly higher rates of hemorrhage, palpable splenomegaly, and anemia. Unexpectedly, however, compared with group B, group A displayed both a higher conversion rate into myelofibrosis/acute leukemia (P = 0.0008) and a shorter median survival (116 vs. 156 months; P = 0.0012). Multivariable analysis including all female patients with ET identified AVT, along with advanced age, leukocytosis, and tobacco use, as an independent risk factor for inferior survival. Groups A, B, and C did not differ in either JAK2V617F mutational frequency or incidence of non-abdominal thrombosis. We conclude that AVT in ET is a marker of aggressive disease biology.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalEuropean Journal of Haematology
Volume77
Issue number4
DOIs
StatePublished - Oct 1 2006

Keywords

  • Budd-Chiari syndrome
  • Hepatic vein thrombosis
  • Leukemic transformation
  • Portal vein thrombosis
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Hematology

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