A survey of susceptibility to infection with Trichinella spiralis of inbred mouse strains sharing common H-2 alleles but different genetic backgrounds

D. L. Wassom, B. O. Brooks, R. H. Cypess, C. S. David

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Twenty-eight different inbred strains of mice representing five different H-2 haplotypes were compared for degree of susceptibility to a primary infection with Trichinella spiralis. Marked differences in susceptibility, measured by the average number of muscle larvae per host, were seen among strains of mice sharing common H-2 alleles. The genes controlling these differences must therefore map at loci outside the major histocompatibility complex. Strains of mice sharing the H-2(k) haplotype were generally more susceptible than strains expressing other haplotypes and strains expressing H-2(q) alleles were most resistant. Strains of mice were ranked in order of decreasing susceptibility. Knowledge of these rankings may be of value to researchers wishing to select strains of mice appropriate for studies on T. spiralis.

Original languageEnglish (US)
Pages (from-to)1033-1037
Number of pages5
JournalJournal of Parasitology
Volume69
Issue number6
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

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