A surveillance study of adenovirus infection in adult solid organ transplant recipients

Atul Humar, Deepali Kumar, Tony Mazzulli, Raymund R. Razonable, George Moussa, Carlos V. Paya, Emma Covington, Emma Alecock, Mark D. Pescovitz

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Little is known about adenovirus infections in adult organ transplant recipients. We prospectively assessed adenovirus infection in 263 transplant recipients using polymerase chain reaction (PCR) on plasma samples at regular intervals post-transplant. Adenovirus DNA was detected in 19 of 263 patients (7.2%). Viremia by transplant type was: liver (n = 10 of 121 [8.3%]), kidney (n = 6 of 92 [6.5%]) and heart (n = 3 of 45 [6.7%]). Time to viremia onset was within 10 days post-transplant (n = 4), on day 28 (n = 1), on day 100 (n = 7) and between months 6 and 12 (n = 7). At the time of viremia, 11 of 19 (58%) patients had no symptoms, 2 of 19 (10.5%) had gastrointestinal (GI) symptoms, 2 of 19 (10.5%) had respiratory symptoms and 4 patients (21%) had vague/non-specific symptoms. All patients recovered spontaneously. Only 1 of 19 (5%) patients had subsequent acute rejection. Adenovirus viremia is relatively common in adult liver, kidney and heart transplant recipients and most infections are asymptomatic, transient and self-limited. No serious clinical sequelae or effects on subsequent acute rejection were observed.

Original languageEnglish (US)
Pages (from-to)2555-2559
Number of pages5
JournalAmerican Journal of Transplantation
Volume5
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • Adenovirus
  • Clinical sequelae
  • Solid organ transplant
  • Viremia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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  • Cite this

    Humar, A., Kumar, D., Mazzulli, T., Razonable, R. R., Moussa, G., Paya, C. V., Covington, E., Alecock, E., & Pescovitz, M. D. (2005). A surveillance study of adenovirus infection in adult solid organ transplant recipients. American Journal of Transplantation, 5(10), 2555-2559. https://doi.org/10.1111/j.1600-6143.2005.01033.x