TY - JOUR
T1 - A Study of HLA Antigens in Alcoholism
AU - ROBERTSON, DENNIS M.
AU - MORSE, ROBERT M.
AU - MOORE, S. BREANNDAN
AU - O'FALLON, WILLIAM M.
AU - HURT, RICHARD D.
PY - 1984
Y1 - 1984
N2 - The concept that alcoholism may be inherited has been suggested on the basis of twin and adoption studies and the further evidence that alcoholism is commonly seen in several members of a family. Genetic marker studies that have been conducted among alcoholics have often yielded seemingly contradictory results. Thus far, genetic marker studies involving HLA antigens have not been used in the study of alcoholism. In the current study, we identified and performed HLA typing in 52 alcoholics to determine whether a significant difference existed between the frequency of HLA-A and HLA-B locus antigens in an alcoholic population and that in a control population consisting of 1,704 nonalcoholic blood donors. In this study, we could not demonstrate a difference in the occurrence of these antigens between the two populations.
AB - The concept that alcoholism may be inherited has been suggested on the basis of twin and adoption studies and the further evidence that alcoholism is commonly seen in several members of a family. Genetic marker studies that have been conducted among alcoholics have often yielded seemingly contradictory results. Thus far, genetic marker studies involving HLA antigens have not been used in the study of alcoholism. In the current study, we identified and performed HLA typing in 52 alcoholics to determine whether a significant difference existed between the frequency of HLA-A and HLA-B locus antigens in an alcoholic population and that in a control population consisting of 1,704 nonalcoholic blood donors. In this study, we could not demonstrate a difference in the occurrence of these antigens between the two populations.
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U2 - 10.1016/S0025-6196(12)61256-7
DO - 10.1016/S0025-6196(12)61256-7
M3 - Article
C2 - 6708601
AN - SCOPUS:0021330973
SN - 0025-6196
VL - 59
SP - 243
EP - 246
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 4
ER -