TY - JOUR
T1 - A single-cell atlas of human and mouse white adipose tissue
AU - Emont, Margo P.
AU - Jacobs, Christopher
AU - Essene, Adam L.
AU - Pant, Deepti
AU - Tenen, Danielle
AU - Colleluori, Georgia
AU - Di Vincenzo, Angelica
AU - Jørgensen, Anja M.
AU - Dashti, Hesam
AU - Stefek, Adam
AU - McGonagle, Elizabeth
AU - Strobel, Sophie
AU - Laber, Samantha
AU - Agrawal, Saaket
AU - Westcott, Gregory P.
AU - Kar, Amrita
AU - Veregge, Molly L.
AU - Gulko, Anton
AU - Srinivasan, Harini
AU - Kramer, Zachary
AU - De Filippis, Eleanna
AU - Merkel, Erin
AU - Ducie, Jennifer
AU - Boyd, Christopher G.
AU - Gourash, William
AU - Courcoulas, Anita
AU - Lin, Samuel J.
AU - Lee, Bernard T.
AU - Morris, Donald
AU - Tobias, Adam
AU - Khera, Amit V.
AU - Claussnitzer, Melina
AU - Pers, Tune H.
AU - Giordano, Antonio
AU - Ashenberg, Orr
AU - Regev, Aviv
AU - Tsai, Linus T.
AU - Rosen, Evan D.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022/3/31
Y1 - 2022/3/31
N2 - White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.
AB - White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.
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UR - http://www.scopus.com/inward/citedby.url?scp=85126384772&partnerID=8YFLogxK
U2 - 10.1038/s41586-022-04518-2
DO - 10.1038/s41586-022-04518-2
M3 - Article
C2 - 35296864
AN - SCOPUS:85126384772
SN - 0028-0836
VL - 603
SP - 926
EP - 933
JO - Nature
JF - Nature
IS - 7903
ER -