Abstract
Multiple myeloma (MM) is a progressive disease that results from dysregulated proliferation of plasma cells. Although, causative factors such as genetic events and altered expression of anti-apoptotic factors have been described in a number of patients, the mechanistic details that drive myeloma development and continued growth of malignant cells remain largely undefined. Numerous growth factors, including interleukin (IL)-6, Insulin-like growth factor-1 and IL-10 have been shown to promote growth of MM cells suggesting a significant role for cytokines in this disease. Interferon (IFN)-λ1 is a new member of the Class II cytokine family that, similar to IFN-α, has been shown to mediate viral immunity. In light of data supporting a role for cytokines in myeloma, we investigated the significance of IFN-λ1 on myeloma cell biology. Our studies show for the first time that myeloma cells bind to soluble IFN-λ1, and that IFN-λ1 induces myeloma cell growth and protects against dexamethasone-induced cell death. Our data also show that IFN-λ1 induces phosphorylation of STAT1, STAT3 and Erk. Taken together, our results suggest that IFN-λ1 may regulate myeloma cell biology and could prove to be therapeutically important.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2240-2246 |
| Number of pages | 7 |
| Journal | Leukemia |
| Volume | 22 |
| Issue number | 12 |
| DOIs | |
| State | Published - 2008 |
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ASJC Scopus subject areas
- Hematology
- Cancer Research
- Anesthesiology and Pain Medicine
- Medicine(all)
Cite this
A role for IFN-λ1 in multiple myeloma B cell growth. / Novak, Anne J; Grote, D. M.; Ziesmer, S. C.; Rajkumar, S Vincent; Doyle, S. E.; Ansell, Stephen Maxted.
In: Leukemia, Vol. 22, No. 12, 2008, p. 2240-2246.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A role for IFN-λ1 in multiple myeloma B cell growth
AU - Novak, Anne J
AU - Grote, D. M.
AU - Ziesmer, S. C.
AU - Rajkumar, S Vincent
AU - Doyle, S. E.
AU - Ansell, Stephen Maxted
PY - 2008
Y1 - 2008
N2 - Multiple myeloma (MM) is a progressive disease that results from dysregulated proliferation of plasma cells. Although, causative factors such as genetic events and altered expression of anti-apoptotic factors have been described in a number of patients, the mechanistic details that drive myeloma development and continued growth of malignant cells remain largely undefined. Numerous growth factors, including interleukin (IL)-6, Insulin-like growth factor-1 and IL-10 have been shown to promote growth of MM cells suggesting a significant role for cytokines in this disease. Interferon (IFN)-λ1 is a new member of the Class II cytokine family that, similar to IFN-α, has been shown to mediate viral immunity. In light of data supporting a role for cytokines in myeloma, we investigated the significance of IFN-λ1 on myeloma cell biology. Our studies show for the first time that myeloma cells bind to soluble IFN-λ1, and that IFN-λ1 induces myeloma cell growth and protects against dexamethasone-induced cell death. Our data also show that IFN-λ1 induces phosphorylation of STAT1, STAT3 and Erk. Taken together, our results suggest that IFN-λ1 may regulate myeloma cell biology and could prove to be therapeutically important.
AB - Multiple myeloma (MM) is a progressive disease that results from dysregulated proliferation of plasma cells. Although, causative factors such as genetic events and altered expression of anti-apoptotic factors have been described in a number of patients, the mechanistic details that drive myeloma development and continued growth of malignant cells remain largely undefined. Numerous growth factors, including interleukin (IL)-6, Insulin-like growth factor-1 and IL-10 have been shown to promote growth of MM cells suggesting a significant role for cytokines in this disease. Interferon (IFN)-λ1 is a new member of the Class II cytokine family that, similar to IFN-α, has been shown to mediate viral immunity. In light of data supporting a role for cytokines in myeloma, we investigated the significance of IFN-λ1 on myeloma cell biology. Our studies show for the first time that myeloma cells bind to soluble IFN-λ1, and that IFN-λ1 induces myeloma cell growth and protects against dexamethasone-induced cell death. Our data also show that IFN-λ1 induces phosphorylation of STAT1, STAT3 and Erk. Taken together, our results suggest that IFN-λ1 may regulate myeloma cell biology and could prove to be therapeutically important.
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UR - http://www.scopus.com/inward/citedby.url?scp=57849093931&partnerID=8YFLogxK
U2 - 10.1038/leu.2008.263
DO - 10.1038/leu.2008.263
M3 - Article
C2 - 18830264
AN - SCOPUS:57849093931
VL - 22
SP - 2240
EP - 2246
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 12
ER -