A role for IFN-λ1 in multiple myeloma B cell growth

Anne J Novak, D. M. Grote, S. C. Ziesmer, S Vincent Rajkumar, S. E. Doyle, Stephen Maxted Ansell

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Multiple myeloma (MM) is a progressive disease that results from dysregulated proliferation of plasma cells. Although, causative factors such as genetic events and altered expression of anti-apoptotic factors have been described in a number of patients, the mechanistic details that drive myeloma development and continued growth of malignant cells remain largely undefined. Numerous growth factors, including interleukin (IL)-6, Insulin-like growth factor-1 and IL-10 have been shown to promote growth of MM cells suggesting a significant role for cytokines in this disease. Interferon (IFN)-λ1 is a new member of the Class II cytokine family that, similar to IFN-α, has been shown to mediate viral immunity. In light of data supporting a role for cytokines in myeloma, we investigated the significance of IFN-λ1 on myeloma cell biology. Our studies show for the first time that myeloma cells bind to soluble IFN-λ1, and that IFN-λ1 induces myeloma cell growth and protects against dexamethasone-induced cell death. Our data also show that IFN-λ1 induces phosphorylation of STAT1, STAT3 and Erk. Taken together, our results suggest that IFN-λ1 may regulate myeloma cell biology and could prove to be therapeutically important.

Original languageEnglish (US)
Pages (from-to)2240-2246
Number of pages7
JournalLeukemia
Volume22
Issue number12
DOIs
StatePublished - 2008

Fingerprint

Multiple Myeloma
Interferons
B-Lymphocytes
Growth
Cytokines
Cell Biology
Somatomedins
Plasma Cells
Growth and Development
Interleukin-10
Dexamethasone
Immunity
Interleukin-6
Intercellular Signaling Peptides and Proteins
Cell Death
Phosphorylation

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine
  • Medicine(all)

Cite this

A role for IFN-λ1 in multiple myeloma B cell growth. / Novak, Anne J; Grote, D. M.; Ziesmer, S. C.; Rajkumar, S Vincent; Doyle, S. E.; Ansell, Stephen Maxted.

In: Leukemia, Vol. 22, No. 12, 2008, p. 2240-2246.

Research output: Contribution to journalArticle

Novak, Anne J ; Grote, D. M. ; Ziesmer, S. C. ; Rajkumar, S Vincent ; Doyle, S. E. ; Ansell, Stephen Maxted. / A role for IFN-λ1 in multiple myeloma B cell growth. In: Leukemia. 2008 ; Vol. 22, No. 12. pp. 2240-2246.
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