A rabbit model of lower eyelid fibrosis

Gregory J. Griepentrog, D. J John Park, Renzo A. Zaldivar, Jose S Pulido, J. Douglas Cameron, John J. Woog

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To create and validate a new model of lower eyelid fibrosis in Dutch-belted rabbits. Methods: Five Dutch-belted rabbits were injected with a transcutaneous 1-ml injection of standard 95% ethanol alcohol just inferior to the eyelid margin of one lower eyelid. A control injection of 1 ml of balanced saline solution was given to the opposite eyelid. A small tattoo was placed on the skin overlying the inferior orbital rim and used as a measuring point of reference in relation to the lower eyelid margin. Analysis was twofold: eyelid measurements were made over 8 weeks to determine the presence of eyelid shortening, and a histopathologic analysis was performed. Results: Mean lower eyelid shortening was greater in the ethanol alcohol intervention eyelids than the control group (-3.4 mm ± 1.67 mm vs. 0.5 mm ± 0.71 mm, p = 0.01). Histopathologic analysis revealed extensive fibrosis in the ethanol alcohol invention eyelids compared with the control group. Conclusions: Ethanol alcohol induces eyelid fibrosis and lower eyelid shortening. This may be a useful model in the future testing of novel surgical or pharmacologic treatments.

Original languageEnglish (US)
Pages (from-to)229-232
Number of pages4
JournalOphthalmic Plastic and Reconstructive Surgery
Volume26
Issue number4
DOIs
StatePublished - Jul 2010

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Eyelids
Fibrosis
Rabbits
Ethanol
Alcohols
Control Groups
Injections
Sodium Chloride

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery
  • Medicine(all)

Cite this

Griepentrog, G. J., Park, D. J. J., Zaldivar, R. A., Pulido, J. S., Cameron, J. D., & Woog, J. J. (2010). A rabbit model of lower eyelid fibrosis. Ophthalmic Plastic and Reconstructive Surgery, 26(4), 229-232. https://doi.org/10.1097/IOP.0b013e3181b8efac

A rabbit model of lower eyelid fibrosis. / Griepentrog, Gregory J.; Park, D. J John; Zaldivar, Renzo A.; Pulido, Jose S; Cameron, J. Douglas; Woog, John J.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 26, No. 4, 07.2010, p. 229-232.

Research output: Contribution to journalArticle

Griepentrog, GJ, Park, DJJ, Zaldivar, RA, Pulido, JS, Cameron, JD & Woog, JJ 2010, 'A rabbit model of lower eyelid fibrosis', Ophthalmic Plastic and Reconstructive Surgery, vol. 26, no. 4, pp. 229-232. https://doi.org/10.1097/IOP.0b013e3181b8efac
Griepentrog, Gregory J. ; Park, D. J John ; Zaldivar, Renzo A. ; Pulido, Jose S ; Cameron, J. Douglas ; Woog, John J. / A rabbit model of lower eyelid fibrosis. In: Ophthalmic Plastic and Reconstructive Surgery. 2010 ; Vol. 26, No. 4. pp. 229-232.
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