A quantitative model for the dynamics of serum prostate-specific antigen as a marker for cancerous growth: An explanation for a medical anomaly

Kristin Swanson, Lawrence D. True, Daniel W. Lin, Kent R. Buhler, Robert Vessella, James D. Murray

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Prostate-specific antigen (PSA) is an enzyme produced by both normal and cancerous prostate epithelial cells. Although PSA is the most widely used serum marker to detect and follow patients with prostatic adenocarcinoma, there are certain anomalies in the values of serum levels of PSA that are not understood. We developed a mathematical model for the dynamics of serum levels of PSA as a function of the tumor volume. Our model results show good agreement with experimental observations and provide an explanation for the existence of significant prostatic tumor mass despite a low-serum PSA. This result can be very useful in enhancing the use of serum PSA levels as a marker for cancer growth.

Original languageEnglish (US)
Pages (from-to)2195-2199
Number of pages5
JournalAmerican Journal of Pathology
Volume158
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Prostate-Specific Antigen
Growth
Serum
Tumor Burden
Prostate
Neoplasms
Adenocarcinoma
Theoretical Models
Biomarkers
Epithelial Cells
Enzymes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A quantitative model for the dynamics of serum prostate-specific antigen as a marker for cancerous growth : An explanation for a medical anomaly. / Swanson, Kristin; True, Lawrence D.; Lin, Daniel W.; Buhler, Kent R.; Vessella, Robert; Murray, James D.

In: American Journal of Pathology, Vol. 158, No. 6, 2001, p. 2195-2199.

Research output: Contribution to journalArticle

Swanson, Kristin ; True, Lawrence D. ; Lin, Daniel W. ; Buhler, Kent R. ; Vessella, Robert ; Murray, James D. / A quantitative model for the dynamics of serum prostate-specific antigen as a marker for cancerous growth : An explanation for a medical anomaly. In: American Journal of Pathology. 2001 ; Vol. 158, No. 6. pp. 2195-2199.
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