A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: The impact of the extent of resection on quality of life and survival

Paul D. Brown, Matthew J. Maurer, Teresa Anne Rummans, Bruce E. Pollock, Karla V Ballman, Jeff A Sloan, Bradley F. Boeve, Robert M. Arusell, Matthew M. Clark, Jan Craig Buckner

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

OBJECTIVE: To describe the quality of life (QOL) over time for adults with newly diagnosed high-grade gliomas and to examine the relationship between QOL and outcome data collected in three prospective cooperative group clinical trials. METHODS: The QOL study was a companion protocol for three Phase II high-grade glioma protocols. Five self-administered forms were completed by patients to assess QOL at study entry, 2 months, and 4 months after enrollment. RESULTS: QOL data were available for baseline, first, and second subsequent follow-up evaluations for 89%, 71%, and 69% of patients, respectively. A significant proportion of patients (47.1%) experienced impaired QOL (QOL ≤ 50) in at least one measure at subsequent evaluations, whereas most patients (88%) with impaired QOL at baseline continued to have impaired QOL at subsequent evaluations. On multivariable analyses, baseline QOL measures were predictive of QOL at the time of follow-up. In addition, patients who underwent a gross total resection were much less likely to have impaired QOL (P = 0.006), were less likely to experience worsening depression (P = 0.0008), and were more likely to have improved QOL (P = 0.003) at their first follow-up evaluation. Changes in QOL measures over time were not found to be associated with survival in multivariable analyses that adjusted for known prognostic variables; variables that were independently associated with improved survival were better performance status (P < 0.001), younger age (P < 0.001), and greater extent of resection (P < 0.001). CONCLUSION: Baseline QOL was predictive of QOL over time. Gross total resection was associated with longer survival and improved QOL over time for patients with high-grade gliomas.

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalNeurosurgery
Volume57
Issue number3
DOIs
StatePublished - Sep 2005

Keywords

  • Glioblastoma
  • High-grade glioma
  • Prospective studies
  • Quality of life
  • Radiotherapy resection

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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