A prospective study of breast lymphedema: Frequency, symptoms, and quality of life

Amy C Degnim, Joyce Miller, Tanya L. Hoskin, Judy C Boughey, Margie Loprinzi, Kristine Thomsen, Shaun Maloney, Larry M. Baddour, Andrea L Cheville

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Although lymphedema of the arm is a wellknown complication of breast and axillary surgery, breast lymphedema has received scant attention. We sought to prospectively characterize breast lymphedema's incidence, associated symptoms, clinical course, and impact on quality of life. Subjects were enrolled prospectively from a consecutive sample of patients undergoing non-mastectomy breast procedures (excisional biopsy or wide local excision ± lymph node removal) and followed for signs and symptoms of lymphedema in the operated breast. Symptoms and distress were serially assessed with 11-point linear analog scales. Breast lymphedema was diagnosed independent of symptoms, based on the distribution and degree of edema and erythema. One hundred twenty-four women were followed for a median of 11 months, and breast lymphedema was diagnosed in 38 (31%) women. Breast lymphedema was more frequent after breast surgery with axillary node removal (49%) compared to breast surgery alone (0%), p < 0.0001. Breast lymphedema involved multiple quadrants in most women and was characterized by edema in 100% and erythema in 79%. Patients with breast lymphedema were significantly more likely than women without breast lymphedema to report symptoms of breast heaviness (65% vs 22%, p<0.0001), redness (62% vs 29%, p = 0.0006), and swelling (59% vs 22%, p\ 0.0001), but symptom-associated distress was low overall. Three of 32 breast lymphedema patients with clinical follow-up developed chronic edema. Breast lymphedema occurs in approximately one-half of women who undergo breast surgery with axillary node removal. The condition is characterized by diffuse skin edema and erythema as well as self-reported symptoms with a low level of distress.

Original languageEnglish (US)
Pages (from-to)915-922
Number of pages8
JournalBreast Cancer Research and Treatment
Volume134
Issue number3
DOIs
StatePublished - Aug 2012

Fingerprint

Lymphedema
Breast
Quality of Life
Prospective Studies
Edema
Erythema
Lymph Node Excision

Keywords

  • Breast edema
  • Breast lymphedema
  • Quality of life
  • Symptom

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A prospective study of breast lymphedema : Frequency, symptoms, and quality of life. / Degnim, Amy C; Miller, Joyce; Hoskin, Tanya L.; Boughey, Judy C; Loprinzi, Margie; Thomsen, Kristine; Maloney, Shaun; Baddour, Larry M.; Cheville, Andrea L.

In: Breast Cancer Research and Treatment, Vol. 134, No. 3, 08.2012, p. 915-922.

Research output: Contribution to journalArticle

Degnim, Amy C ; Miller, Joyce ; Hoskin, Tanya L. ; Boughey, Judy C ; Loprinzi, Margie ; Thomsen, Kristine ; Maloney, Shaun ; Baddour, Larry M. ; Cheville, Andrea L. / A prospective study of breast lymphedema : Frequency, symptoms, and quality of life. In: Breast Cancer Research and Treatment. 2012 ; Vol. 134, No. 3. pp. 915-922.
@article{8ff027d712f44869a2467b544974e667,
title = "A prospective study of breast lymphedema: Frequency, symptoms, and quality of life",
abstract = "Although lymphedema of the arm is a wellknown complication of breast and axillary surgery, breast lymphedema has received scant attention. We sought to prospectively characterize breast lymphedema's incidence, associated symptoms, clinical course, and impact on quality of life. Subjects were enrolled prospectively from a consecutive sample of patients undergoing non-mastectomy breast procedures (excisional biopsy or wide local excision ± lymph node removal) and followed for signs and symptoms of lymphedema in the operated breast. Symptoms and distress were serially assessed with 11-point linear analog scales. Breast lymphedema was diagnosed independent of symptoms, based on the distribution and degree of edema and erythema. One hundred twenty-four women were followed for a median of 11 months, and breast lymphedema was diagnosed in 38 (31{\%}) women. Breast lymphedema was more frequent after breast surgery with axillary node removal (49{\%}) compared to breast surgery alone (0{\%}), p < 0.0001. Breast lymphedema involved multiple quadrants in most women and was characterized by edema in 100{\%} and erythema in 79{\%}. Patients with breast lymphedema were significantly more likely than women without breast lymphedema to report symptoms of breast heaviness (65{\%} vs 22{\%}, p<0.0001), redness (62{\%} vs 29{\%}, p = 0.0006), and swelling (59{\%} vs 22{\%}, p\ 0.0001), but symptom-associated distress was low overall. Three of 32 breast lymphedema patients with clinical follow-up developed chronic edema. Breast lymphedema occurs in approximately one-half of women who undergo breast surgery with axillary node removal. The condition is characterized by diffuse skin edema and erythema as well as self-reported symptoms with a low level of distress.",
keywords = "Breast edema, Breast lymphedema, Quality of life, Symptom",
author = "Degnim, {Amy C} and Joyce Miller and Hoskin, {Tanya L.} and Boughey, {Judy C} and Margie Loprinzi and Kristine Thomsen and Shaun Maloney and Baddour, {Larry M.} and Cheville, {Andrea L}",
year = "2012",
month = "8",
doi = "10.1007/s10549-012-2004-x",
language = "English (US)",
volume = "134",
pages = "915--922",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - A prospective study of breast lymphedema

T2 - Frequency, symptoms, and quality of life

AU - Degnim, Amy C

AU - Miller, Joyce

AU - Hoskin, Tanya L.

AU - Boughey, Judy C

AU - Loprinzi, Margie

AU - Thomsen, Kristine

AU - Maloney, Shaun

AU - Baddour, Larry M.

AU - Cheville, Andrea L

PY - 2012/8

Y1 - 2012/8

N2 - Although lymphedema of the arm is a wellknown complication of breast and axillary surgery, breast lymphedema has received scant attention. We sought to prospectively characterize breast lymphedema's incidence, associated symptoms, clinical course, and impact on quality of life. Subjects were enrolled prospectively from a consecutive sample of patients undergoing non-mastectomy breast procedures (excisional biopsy or wide local excision ± lymph node removal) and followed for signs and symptoms of lymphedema in the operated breast. Symptoms and distress were serially assessed with 11-point linear analog scales. Breast lymphedema was diagnosed independent of symptoms, based on the distribution and degree of edema and erythema. One hundred twenty-four women were followed for a median of 11 months, and breast lymphedema was diagnosed in 38 (31%) women. Breast lymphedema was more frequent after breast surgery with axillary node removal (49%) compared to breast surgery alone (0%), p < 0.0001. Breast lymphedema involved multiple quadrants in most women and was characterized by edema in 100% and erythema in 79%. Patients with breast lymphedema were significantly more likely than women without breast lymphedema to report symptoms of breast heaviness (65% vs 22%, p<0.0001), redness (62% vs 29%, p = 0.0006), and swelling (59% vs 22%, p\ 0.0001), but symptom-associated distress was low overall. Three of 32 breast lymphedema patients with clinical follow-up developed chronic edema. Breast lymphedema occurs in approximately one-half of women who undergo breast surgery with axillary node removal. The condition is characterized by diffuse skin edema and erythema as well as self-reported symptoms with a low level of distress.

AB - Although lymphedema of the arm is a wellknown complication of breast and axillary surgery, breast lymphedema has received scant attention. We sought to prospectively characterize breast lymphedema's incidence, associated symptoms, clinical course, and impact on quality of life. Subjects were enrolled prospectively from a consecutive sample of patients undergoing non-mastectomy breast procedures (excisional biopsy or wide local excision ± lymph node removal) and followed for signs and symptoms of lymphedema in the operated breast. Symptoms and distress were serially assessed with 11-point linear analog scales. Breast lymphedema was diagnosed independent of symptoms, based on the distribution and degree of edema and erythema. One hundred twenty-four women were followed for a median of 11 months, and breast lymphedema was diagnosed in 38 (31%) women. Breast lymphedema was more frequent after breast surgery with axillary node removal (49%) compared to breast surgery alone (0%), p < 0.0001. Breast lymphedema involved multiple quadrants in most women and was characterized by edema in 100% and erythema in 79%. Patients with breast lymphedema were significantly more likely than women without breast lymphedema to report symptoms of breast heaviness (65% vs 22%, p<0.0001), redness (62% vs 29%, p = 0.0006), and swelling (59% vs 22%, p\ 0.0001), but symptom-associated distress was low overall. Three of 32 breast lymphedema patients with clinical follow-up developed chronic edema. Breast lymphedema occurs in approximately one-half of women who undergo breast surgery with axillary node removal. The condition is characterized by diffuse skin edema and erythema as well as self-reported symptoms with a low level of distress.

KW - Breast edema

KW - Breast lymphedema

KW - Quality of life

KW - Symptom

UR - http://www.scopus.com/inward/record.url?scp=84868194407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868194407&partnerID=8YFLogxK

U2 - 10.1007/s10549-012-2004-x

DO - 10.1007/s10549-012-2004-x

M3 - Article

C2 - 22415476

AN - SCOPUS:84868194407

VL - 134

SP - 915

EP - 922

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 3

ER -