Abstract
Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1893-1901 |
| Number of pages | 9 |
| Journal | Multiple Sclerosis Journal |
| Volume | 23 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jan 1 2017 |
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Keywords
- Biomarkers
- Clinically isolated syndrome
- Epidemiology
- MRI
- Multiple sclerosis
- Neuromyelitis optica spectrum disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
A population-based prospective study of optic neuritis. / Soelberg, K.; Jarius, S.; Skejoe, H. P.B.; Engberg, H.; Mehlsen, J. J.; Nilsson, A. C.; Madsen, J. S.; Reindl, M.; Wildemann, B.; Grauslund, J.; Kyvik, K. O.; Smith, T. J.; Lillevang, S. T.; Paul, F.; Weinshenker, Brian G; Asgari, N.
In: Multiple Sclerosis Journal, Vol. 23, No. 14, 01.01.2017, p. 1893-1901.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A population-based prospective study of optic neuritis
AU - Soelberg, K.
AU - Jarius, S.
AU - Skejoe, H. P.B.
AU - Engberg, H.
AU - Mehlsen, J. J.
AU - Nilsson, A. C.
AU - Madsen, J. S.
AU - Reindl, M.
AU - Wildemann, B.
AU - Grauslund, J.
AU - Kyvik, K. O.
AU - Smith, T. J.
AU - Lillevang, S. T.
AU - Paul, F.
AU - Weinshenker, Brian G
AU - Asgari, N.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.
AB - Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.
KW - Biomarkers
KW - Clinically isolated syndrome
KW - Epidemiology
KW - MRI
KW - Multiple sclerosis
KW - Neuromyelitis optica spectrum disease
UR - http://www.scopus.com/inward/record.url?scp=85043326459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043326459&partnerID=8YFLogxK
U2 - 10.1177/1352458517734070
DO - 10.1177/1352458517734070
M3 - Article
AN - SCOPUS:85043326459
VL - 23
SP - 1893
EP - 1901
JO - Multiple Sclerosis
JF - Multiple Sclerosis
SN - 1352-4585
IS - 14
ER -