A population-based prospective study of optic neuritis

K. Soelberg, S. Jarius, H. P.B. Skejoe, H. Engberg, J. J. Mehlsen, A. C. Nilsson, J. S. Madsen, M. Reindl, B. Wildemann, J. Grauslund, K. O. Kyvik, T. J. Smith, S. T. Lillevang, F. Paul, Brian G Weinshenker, N. Asgari

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

Original languageEnglish (US)
Pages (from-to)1893-1901
Number of pages9
JournalMultiple Sclerosis Journal
Volume23
Issue number14
DOIs
StatePublished - Jan 1 2017

Fingerprint

Optic Neuritis
Prospective Studies
Myelin-Oligodendrocyte Glycoprotein
Population
Multiple Sclerosis
Immunoglobulin G
Aquaporin 4
Magnetic Resonance Imaging
Incidence
Neurologic Examination
Early Diagnosis
Antibodies

Keywords

  • Biomarkers
  • Clinically isolated syndrome
  • Epidemiology
  • MRI
  • Multiple sclerosis
  • Neuromyelitis optica spectrum disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Soelberg, K., Jarius, S., Skejoe, H. P. B., Engberg, H., Mehlsen, J. J., Nilsson, A. C., ... Asgari, N. (2017). A population-based prospective study of optic neuritis. Multiple Sclerosis Journal, 23(14), 1893-1901. https://doi.org/10.1177/1352458517734070

A population-based prospective study of optic neuritis. / Soelberg, K.; Jarius, S.; Skejoe, H. P.B.; Engberg, H.; Mehlsen, J. J.; Nilsson, A. C.; Madsen, J. S.; Reindl, M.; Wildemann, B.; Grauslund, J.; Kyvik, K. O.; Smith, T. J.; Lillevang, S. T.; Paul, F.; Weinshenker, Brian G; Asgari, N.

In: Multiple Sclerosis Journal, Vol. 23, No. 14, 01.01.2017, p. 1893-1901.

Research output: Contribution to journalArticle

Soelberg, K, Jarius, S, Skejoe, HPB, Engberg, H, Mehlsen, JJ, Nilsson, AC, Madsen, JS, Reindl, M, Wildemann, B, Grauslund, J, Kyvik, KO, Smith, TJ, Lillevang, ST, Paul, F, Weinshenker, BG & Asgari, N 2017, 'A population-based prospective study of optic neuritis', Multiple Sclerosis Journal, vol. 23, no. 14, pp. 1893-1901. https://doi.org/10.1177/1352458517734070
Soelberg K, Jarius S, Skejoe HPB, Engberg H, Mehlsen JJ, Nilsson AC et al. A population-based prospective study of optic neuritis. Multiple Sclerosis Journal. 2017 Jan 1;23(14):1893-1901. https://doi.org/10.1177/1352458517734070
Soelberg, K. ; Jarius, S. ; Skejoe, H. P.B. ; Engberg, H. ; Mehlsen, J. J. ; Nilsson, A. C. ; Madsen, J. S. ; Reindl, M. ; Wildemann, B. ; Grauslund, J. ; Kyvik, K. O. ; Smith, T. J. ; Lillevang, S. T. ; Paul, F. ; Weinshenker, Brian G ; Asgari, N. / A population-based prospective study of optic neuritis. In: Multiple Sclerosis Journal. 2017 ; Vol. 23, No. 14. pp. 1893-1901.
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abstract = "Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86{\%}) had a single episode of ON (four bilateral), while 7/51 (14{\%}) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4{\%} of cases.",
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AU - Soelberg, K.

AU - Jarius, S.

AU - Skejoe, H. P.B.

AU - Engberg, H.

AU - Mehlsen, J. J.

AU - Nilsson, A. C.

AU - Madsen, J. S.

AU - Reindl, M.

AU - Wildemann, B.

AU - Grauslund, J.

AU - Kyvik, K. O.

AU - Smith, T. J.

AU - Lillevang, S. T.

AU - Paul, F.

AU - Weinshenker, Brian G

AU - Asgari, N.

PY - 2017/1/1

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N2 - Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

AB - Background: Optic neuritis (ON) is often associated with multiple sclerosis (MS). Early diagnosis is critical to optimal patient management. Objective: To estimate the incidence of acute ON and the rates of conversion to MS and antibodymediated ON. Method: Population-based prospective study was performed in patients with ON from three ophthalmological departments and 44 practicing ophthalmologists from 2014 to 2016. Ophthalmological and neurological examination, magnetic resonance imaging (MRI), determination of aquaporin-4(AQP4)-IgG and myelin-oligodendrocyte glycoprotein (MOG)-IgG were investigated blindly. Results: In all, 63 patients were evaluated and 51 fulfilled the criteria for ON. All were Caucasian, with female:male ratio of 2.2:1 and a median age of 38 years (16–66); 44 (86%) had a single episode of ON (four bilateral), while 7/51 (14%) had recurrent ON. The overall age-specific incidence was 3.28 (2.44–4.31) per 100,000 person years, 2.02 for men and 4.57 for women. At follow-up, 20 patients met the diagnostic criteria for MS, MRI lesions disseminated in space and time in 17/20 patients. AQP4-IgG was detected in none, MOG-IgG was detected in two patients. Conclusion: The prospective incidence of ON was estimated. MRI enabled a diagnosis of MS in a subgroup of patients. Antibody-mediated ON with specificity for MOG was detected in 4% of cases.

KW - Biomarkers

KW - Clinically isolated syndrome

KW - Epidemiology

KW - MRI

KW - Multiple sclerosis

KW - Neuromyelitis optica spectrum disease

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