A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner

Steve M. Jorgensen, Michael S. Chmelik, Diane R. Eaker, Carolyn A. MacDonald, Erik L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

To show the feasibility of a combined micro-CT and micro-SPECT scanner based on use of polycapillary optics we inserted an optic between the radio-labeled specimen and our micro-CT scanner's imaging system. The micro-CT x-ray focal spot was placed at the focal point of the optic so that x-ray micro-CT of the specimen could also be performed without having to move the specimen. Using this set-up we scanned a 2 cm diameter Plexiglas cylinder with three (177 μCi) prostate brachytherapy seeds embedded in it. Each seed was 0.5 mm diameter, 4 mm long and filled with 0.4 mm diameter ceramic beads coated with 125Iodine. The SPECT images clearly resolve the layer of 125Iodine on the beads. That the SPECT image is spatially correct was confirmed by the concurrent CT image. We also used a parallel polycapillary optic to scan a 1.5cm Plexiglas cylinder with holes (2, 1, and 0.5 mm diameter, parallel to the cylinder axis) filled with a solution containing 11.56μCi/mm 3 of 125Iodine. These data indicate a spatial resolution of 5 line pairs per mm at 10% modulation. Based on these results we propose a design that is more efficient at acquiring the scintigraphic image data.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsU. Bonse
Pages36-42
Number of pages7
Volume5535
DOIs
StatePublished - 2004
Externally publishedYes
EventDevelopments in X-Ray Tomography IV - Denver, CO, United States
Duration: Aug 4 2004Aug 6 2004

Other

OtherDevelopments in X-Ray Tomography IV
CountryUnited States
CityDenver, CO
Period8/4/048/6/04

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Keywords

  • Iodine
  • Collimation
  • Computed tomography
  • Cone beam x-ray
  • Spatial resolution
  • X-ray optic

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Jorgensen, S. M., Chmelik, M. S., Eaker, D. R., MacDonald, C. A., & Ritman, E. L. (2004). A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner. In U. Bonse (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5535, pp. 36-42). [05] https://doi.org/10.1117/12.560991