A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108

Alison T. Stopeck, Joseph M. Unger, Lisa M. Rimsza, William T. Bellamy, Maria Iannone, Daniel Persky, Michael Leblanc, Richard Fisher, Thomas Miller

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

This is the first report of the Southwest oncology group phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma (NHL). Fifty-two patients in first or second relapse with diffuse large B-cell or mantle cell lymphoma were enrolled. Patients were treated with bevacizumab at 10 mg/kg every 2 weeks. Therapy was well tolerated with no unexpected toxicities observed. Six-month progression-free survival (PFS) was 16% with a response rate of 2% and median duration of response or stable disease of 5.2 months (range 3.5-72.7). Vascular endothelial growth factor A (VEGF) and VEGF receptor expression was observed in 70% and 65% of specimens, respectively. In an exploratory subgroup analysis, baseline urine VEGF and plasma vascular cell adhesion molecule-1 (VCAM) levels correlated with survival. Prolonged PFS in several patients as well as biomarker studies suggest the VEGF pathway plays an important role in aggressive NHL. Clinical trials combining active chemotherapy regimens with VEGF targeted agents are currently in progress.

Original languageEnglish (US)
Pages (from-to)728-735
Number of pages8
JournalLeukemia and Lymphoma
Volume50
Issue number5
DOIs
StatePublished - Aug 17 2009

Keywords

  • Bevacizumab
  • Clinical trial
  • Non-Hodgkin lymphoma
  • VEGF

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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