A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction

Georges Mer, Maria Victoria Botuyan

Research output: Contribution to journalShort survey

Abstract

Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1. Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1.

Original languageEnglish (US)
Pages (from-to)1471-1472
Number of pages2
JournalStructure
Volume25
Issue number10
DOIs
StatePublished - Oct 3 2017

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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