A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction

Georges Mer, Maria Victoria Botuyan

Research output: Contribution to journalShort survey

Abstract

Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1. Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1.

Original languageEnglish (US)
Pages (from-to)1471-1472
Number of pages2
JournalStructure
Volume25
Issue number10
DOIs
StatePublished - Oct 3 2017

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Bloom Syndrome
Solar System
Bloom syndrome protein

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction. / Mer, Georges; Botuyan, Maria Victoria.

In: Structure, Vol. 25, No. 10, 03.10.2017, p. 1471-1472.

Research output: Contribution to journalShort survey

Mer, Georges ; Botuyan, Maria Victoria. / A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction. In: Structure. 2017 ; Vol. 25, No. 10. pp. 1471-1472.
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