A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells

N. V. Shirsat, Robert Pignolo, B. L. Kreider, G. Rovera

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoietic lineages and the mRNA levels increase with the terminal differentiation of hemopoietic cells into granulocytes.

Original languageEnglish (US)
Pages (from-to)769-772
Number of pages4
JournalOncogene
Volume5
Issue number5
StatePublished - Jun 6 1990
Externally publishedYes

Fingerprint

ras Genes
Myeloid Cells
Oligonucleotide Probes
Cell Lineage
Granulocytes
Northern Blotting
Protein-Tyrosine Kinases
Cell Differentiation
Complementary DNA
Gene Expression
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. / Shirsat, N. V.; Pignolo, Robert; Kreider, B. L.; Rovera, G.

In: Oncogene, Vol. 5, No. 5, 06.06.1990, p. 769-772.

Research output: Contribution to journalArticle

Shirsat, N. V. ; Pignolo, Robert ; Kreider, B. L. ; Rovera, G. / A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells. In: Oncogene. 1990 ; Vol. 5, No. 5. pp. 769-772.
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