A genetic animal model of human neocortical heterotopia associated with seizures

Kevin S. Lee, Frank Schottler, Jennifer L. Collins, Giuseppe Lanzino, Daniel Couture, Anand Rao, Ken Ichiro Hiramatsu, Yasunobu Goto, Seung Chyul Hong, Hakan Caner, Haruaki Yamamoto, Zong Fu Chen, Edward Bertram, Stuart Berr, Reed Omary, Heidi Scrable, Theodore Jackson, John Goble, Leonard Eisenman

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Malformations of the human neocortex are commonly associated with developmental delays, mental retardation, and epilepsy. This study describes a novel neurologically mutant rat exhibiting a forebrain anomaly resembling the human neuronal migration disorder of double cortex. This mutant displays a telencephalic internal structural heterotopia (tish) that is inherited in an autosomal recessive manner. The bilateral heterotopia is prominent below the frontal and parietal neocortices but is rarely observed in temporal neocortex. Neurons in the heterotopia exhibit neocortical-like morphologies and send typical projections to subcortical sites; however, characteristic lamination and radial orientation are disturbed in the heterotopia. The period of neurogenesis during which cells in the heterotopia are generated is the same as in the normotopic neocortex; however, the cells in the heterotopia exhibit a 'rim-to-core' neurogenetic pattern rather than the characteristic 'inside-out' pattern observed in normotopic neocortex. Similar to the human syndrome of double cortex, some of the animals with the fish phenotype exhibit spontaneous recurrent electrographic and behavioral seizures. The tish rat is a unique neurological mutant that shares several features with a human cortical malformation associated with epilepsy. On the basis of its regional connectivity, histological composition, and period of neurogenesis, the heterotopic region in the tish rat is neocortical in nature. This neurological mutant represents a novel model system for investigating mechanisms of aberrant neocortical development and is likely to provide insights into the cellular and molecular events contributing to seizure development in dysplastic neocortex.

Original languageEnglish (US)
Pages (from-to)6236-6242
Number of pages7
JournalJournal of Neuroscience
Volume17
Issue number16
StatePublished - Aug 15 1997
Externally publishedYes

Fingerprint

Genetic Models
Neocortex
Seizures
Animal Models
Telencephalon
Neurogenesis
Epilepsy
Group II Malformations of Cortical Development
Classical Lissencephalies and Subcortical Band Heterotopias
Prosencephalon
Intellectual Disability
Fishes
Phenotype
Neurons

Keywords

  • Cortical heterotopia
  • Double cortex
  • Epilepsy
  • Neurogenesis
  • Neuronal migration disorder
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lee, K. S., Schottler, F., Collins, J. L., Lanzino, G., Couture, D., Rao, A., ... Eisenman, L. (1997). A genetic animal model of human neocortical heterotopia associated with seizures. Journal of Neuroscience, 17(16), 6236-6242.

A genetic animal model of human neocortical heterotopia associated with seizures. / Lee, Kevin S.; Schottler, Frank; Collins, Jennifer L.; Lanzino, Giuseppe; Couture, Daniel; Rao, Anand; Hiramatsu, Ken Ichiro; Goto, Yasunobu; Hong, Seung Chyul; Caner, Hakan; Yamamoto, Haruaki; Chen, Zong Fu; Bertram, Edward; Berr, Stuart; Omary, Reed; Scrable, Heidi; Jackson, Theodore; Goble, John; Eisenman, Leonard.

In: Journal of Neuroscience, Vol. 17, No. 16, 15.08.1997, p. 6236-6242.

Research output: Contribution to journalArticle

Lee, KS, Schottler, F, Collins, JL, Lanzino, G, Couture, D, Rao, A, Hiramatsu, KI, Goto, Y, Hong, SC, Caner, H, Yamamoto, H, Chen, ZF, Bertram, E, Berr, S, Omary, R, Scrable, H, Jackson, T, Goble, J & Eisenman, L 1997, 'A genetic animal model of human neocortical heterotopia associated with seizures', Journal of Neuroscience, vol. 17, no. 16, pp. 6236-6242.
Lee KS, Schottler F, Collins JL, Lanzino G, Couture D, Rao A et al. A genetic animal model of human neocortical heterotopia associated with seizures. Journal of Neuroscience. 1997 Aug 15;17(16):6236-6242.
Lee, Kevin S. ; Schottler, Frank ; Collins, Jennifer L. ; Lanzino, Giuseppe ; Couture, Daniel ; Rao, Anand ; Hiramatsu, Ken Ichiro ; Goto, Yasunobu ; Hong, Seung Chyul ; Caner, Hakan ; Yamamoto, Haruaki ; Chen, Zong Fu ; Bertram, Edward ; Berr, Stuart ; Omary, Reed ; Scrable, Heidi ; Jackson, Theodore ; Goble, John ; Eisenman, Leonard. / A genetic animal model of human neocortical heterotopia associated with seizures. In: Journal of Neuroscience. 1997 ; Vol. 17, No. 16. pp. 6236-6242.
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abstract = "Malformations of the human neocortex are commonly associated with developmental delays, mental retardation, and epilepsy. This study describes a novel neurologically mutant rat exhibiting a forebrain anomaly resembling the human neuronal migration disorder of double cortex. This mutant displays a telencephalic internal structural heterotopia (tish) that is inherited in an autosomal recessive manner. The bilateral heterotopia is prominent below the frontal and parietal neocortices but is rarely observed in temporal neocortex. Neurons in the heterotopia exhibit neocortical-like morphologies and send typical projections to subcortical sites; however, characteristic lamination and radial orientation are disturbed in the heterotopia. The period of neurogenesis during which cells in the heterotopia are generated is the same as in the normotopic neocortex; however, the cells in the heterotopia exhibit a 'rim-to-core' neurogenetic pattern rather than the characteristic 'inside-out' pattern observed in normotopic neocortex. Similar to the human syndrome of double cortex, some of the animals with the fish phenotype exhibit spontaneous recurrent electrographic and behavioral seizures. The tish rat is a unique neurological mutant that shares several features with a human cortical malformation associated with epilepsy. On the basis of its regional connectivity, histological composition, and period of neurogenesis, the heterotopic region in the tish rat is neocortical in nature. This neurological mutant represents a novel model system for investigating mechanisms of aberrant neocortical development and is likely to provide insights into the cellular and molecular events contributing to seizure development in dysplastic neocortex.",
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