A genetic animal model of human neocortical heterotopia associated with seizures

Kevin S. Lee, Frank Schottler, Jennifer L. Collins, Giuseppe Lanzino, Daniel Couture, Anand Rao, Ken Ichiro Hiramatsu, Yasunobu Goto, Seung Chyul Hong, Hakan Caner, Haruaki Yamamoto, Zong Fu Chen, Edward Bertram, Stuart Berr, Reed Omary, Heidi Scrable, Theodore Jackson, John Goble, Leonard Eisenman

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Malformations of the human neocortex are commonly associated with developmental delays, mental retardation, and epilepsy. This study describes a novel neurologically mutant rat exhibiting a forebrain anomaly resembling the human neuronal migration disorder of double cortex. This mutant displays a telencephalic internal structural heterotopia (tish) that is inherited in an autosomal recessive manner. The bilateral heterotopia is prominent below the frontal and parietal neocortices but is rarely observed in temporal neocortex. Neurons in the heterotopia exhibit neocortical-like morphologies and send typical projections to subcortical sites; however, characteristic lamination and radial orientation are disturbed in the heterotopia. The period of neurogenesis during which cells in the heterotopia are generated is the same as in the normotopic neocortex; however, the cells in the heterotopia exhibit a 'rim-to-core' neurogenetic pattern rather than the characteristic 'inside-out' pattern observed in normotopic neocortex. Similar to the human syndrome of double cortex, some of the animals with the fish phenotype exhibit spontaneous recurrent electrographic and behavioral seizures. The tish rat is a unique neurological mutant that shares several features with a human cortical malformation associated with epilepsy. On the basis of its regional connectivity, histological composition, and period of neurogenesis, the heterotopic region in the tish rat is neocortical in nature. This neurological mutant represents a novel model system for investigating mechanisms of aberrant neocortical development and is likely to provide insights into the cellular and molecular events contributing to seizure development in dysplastic neocortex.

Original languageEnglish (US)
Pages (from-to)6236-6242
Number of pages7
JournalJournal of Neuroscience
Volume17
Issue number16
DOIs
StatePublished - Aug 15 1997

Keywords

  • Cortical heterotopia
  • Double cortex
  • Epilepsy
  • Neurogenesis
  • Neuronal migration disorder
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lee, K. S., Schottler, F., Collins, J. L., Lanzino, G., Couture, D., Rao, A., Hiramatsu, K. I., Goto, Y., Hong, S. C., Caner, H., Yamamoto, H., Chen, Z. F., Bertram, E., Berr, S., Omary, R., Scrable, H., Jackson, T., Goble, J., & Eisenman, L. (1997). A genetic animal model of human neocortical heterotopia associated with seizures. Journal of Neuroscience, 17(16), 6236-6242. https://doi.org/10.1523/jneurosci.17-16-06236.1997