A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma

Rabia Zafar, Lacey J. Schrader, John C. Cheville, J. Kenneth Schoolmeester, Anja C. Roden, Marie Christine Aubry, Joanne E.S. Yi, Aditya Raghunathan, Loren Herrera-Hernandez, R. Houston Thompson, Stephen A Boorjian, Bradley C. Leibovich, Gary L. Keeney, Rafael E Jimenez, Sounak Gupta

Research output: Contribution to journalArticlepeer-review

Abstract

As there is limited literature on paratesticular tumors of müllerian and mesothelial origin, we reviewed archived cases of serous borderline tumors (n = 15), low-grade serous carcinoma (n = 1), well-differentiated papillary mesothelial tumors (WDPMTs; n = 2), and mesothelioma (n = 12), for relevant clinicopathologic features. Molecular profiling data from the American Association for Cancer Research (AACR) GENIE registry was accessed for 8 additional patients with testicular mesothelioma. For tumors of mesothelial origin, the median age at surgical excision was 62 years, the median size was 4.5 cm, and they consistently exhibited positivity for mesothelial markers (CK5/6, calretinin, WT1, and D2-40). Recurrent alterations of the NF2 gene were identified in 3 of 8 patients (38%), and alterations of BAP1 and CDKN2A were relatively infrequent. While one patient with WDPMT had a recurrence, a second patient with WDPMT progressed to a biphasic mesothelioma 2 years after initial resection. For tumors of müllerian origin, the median age at surgical excision was 45 years, the median size was 2.5 cm, and these exhibited consistent positivity for ER, WT1, and PAX8. Although no recurrences were documented in patients with serous borderline tumors, a single patient with a low-grade serous carcinoma developed widely metastatic disease and died of disease-related complications. Our study emphasizes the need for close clinical follow-up in patients with WDPMT and highlights the prognostic significance of documenting invasive behavior in tumors of müllerian origin as they can have an aggressive clinical course. Finally, our results suggest that NF2 alterations may play an important role in the pathogenesis of testicular mesothelioma.

Original languageEnglish (US)
Pages (from-to)31-47
Number of pages17
JournalHuman Pathology
Volume128
DOIs
StatePublished - Oct 2022

Keywords

  • Testicular low-grade serous carcinoma
  • Testicular mesothelioma
  • Testicular serous borderline tumor
  • Testicular well-differentiated papillary mesothelial tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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