TY - JOUR
T1 - A Descriptive Study of Late Intensive Care Unit Admissions After Adult Solitary Kidney Transplantation
AU - Abrol, Nitin
AU - Kashani, Kianoush B.
AU - Prieto, Mikel
AU - Taner, Timucin
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/4
Y1 - 2021/4
N2 - Objective: Kidney transplant recipients are at lifetime risk of requiring high acuity care. In the current study, we aimed to assess the reasons for delayed (> 30 days) intensive care unit (ICU) admissions post-transplant and causes of ICU-related mortality. Methods: This is a retrospective study of a cohort of adult kidney transplant patients from January 1, 2007, through December 31, 2016, who required ICU admission after 30 days of transplantation. The admissions were divided into 3 groups based on their timeline between transplantation and ICU admission: 1. group 1 from 30 days to 6 months, 2. group 2 between 6-24 months, and 3. group 3 after 2 years. All admissions were categorized according to the primary organ system involved. Results: A total of 285 (group 1: 50, group 2: 89, group 3: 146) patients required 404 ICU admissions (group 1: 57, group 2: 108, group 3: 239). Overall, cardiovascular system-related admissions (29.9%, 18.5%, 15.9%), infections (19.3%, 25.9%, 27.2%), and respiratory-related admissions (12.3%, 8.3%, 8.8%) were main causes in all 3 groups. A total of 24 (8.4%) patients died in the ICU. Most of the deaths occurred in men (79.2%), infection-related admissions (45.8%), and individuals with a functioning allograft (66.7%). Infections (45.8%) were the main causes of ICU-related mortality. Median time from transplantation to death was 2.3 years (interquartile range: 1.2-4.6). Conclusion: Kidney transplant patients continue to be at risk of requiring high acuity care long after transplantation. Most of these admissions are related to cardiopulmonary system involvement or infections. Overall, infections were the leading cause of ICU-related mortality.
AB - Objective: Kidney transplant recipients are at lifetime risk of requiring high acuity care. In the current study, we aimed to assess the reasons for delayed (> 30 days) intensive care unit (ICU) admissions post-transplant and causes of ICU-related mortality. Methods: This is a retrospective study of a cohort of adult kidney transplant patients from January 1, 2007, through December 31, 2016, who required ICU admission after 30 days of transplantation. The admissions were divided into 3 groups based on their timeline between transplantation and ICU admission: 1. group 1 from 30 days to 6 months, 2. group 2 between 6-24 months, and 3. group 3 after 2 years. All admissions were categorized according to the primary organ system involved. Results: A total of 285 (group 1: 50, group 2: 89, group 3: 146) patients required 404 ICU admissions (group 1: 57, group 2: 108, group 3: 239). Overall, cardiovascular system-related admissions (29.9%, 18.5%, 15.9%), infections (19.3%, 25.9%, 27.2%), and respiratory-related admissions (12.3%, 8.3%, 8.8%) were main causes in all 3 groups. A total of 24 (8.4%) patients died in the ICU. Most of the deaths occurred in men (79.2%), infection-related admissions (45.8%), and individuals with a functioning allograft (66.7%). Infections (45.8%) were the main causes of ICU-related mortality. Median time from transplantation to death was 2.3 years (interquartile range: 1.2-4.6). Conclusion: Kidney transplant patients continue to be at risk of requiring high acuity care long after transplantation. Most of these admissions are related to cardiopulmonary system involvement or infections. Overall, infections were the leading cause of ICU-related mortality.
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U2 - 10.1016/j.transproceed.2021.01.031
DO - 10.1016/j.transproceed.2021.01.031
M3 - Article
C2 - 33573818
AN - SCOPUS:85100665904
SN - 0041-1345
VL - 53
SP - 1095
EP - 1099
JO - Transplantation proceedings
JF - Transplantation proceedings
IS - 3
ER -