A current review of molecular mechanisms regarding osteoarthritis and pain

Andrew S. Lee, Michael B. Ellman, Dongyao Yan, Jeffrey S. Kroin, Brian J. Cole, Andre J. van Wijnen, Hee Jeong Im

Research output: Contribution to journalReview article

206 Scopus citations

Abstract

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of life and increased health costs. To understand this disease, physicians have been studying risk factors, such as genetic predisposition, aging, obesity, and joint malalignment; however have been unable to conclusively determine the direct etiology. Current treatment options are short-term or ineffective and fail to address pathophysiological and biochemical mechanisms involved with cartilage degeneration and the induction of pain in arthritic joints. OA pain involves a complex integration of sensory, affective, and cognitive processes that integrate a variety of abnormal cellular mechanisms at both peripheral and central (spinal and supraspinal) levels of the nervous system Through studies examined by investigators, the role of growth factors and cytokines has increasingly become more relevant in examining their effects on articular cartilage homeostasis and the development of osteoarthritis and osteoarthritis-associated pain. Catabolic factors involved in both cartilage degradation in vitro and nociceptive stimulation include IL-1, IL-6, TNF-α, PGE2, FGF-2 and PKCδ, and pharmacologic inhibitors to these mediators, as well as compounds such as RSV and LfcinB, may potentially be used as biological treatments in the future. This review explores several biochemical mediators involved in OA and pain, and provides a framework for the understanding of potential biologic therapies in the treatment of degenerative joint disease in the future.

Original languageEnglish (US)
Pages (from-to)440-447
Number of pages8
JournalGene
Volume527
Issue number2
DOIs
StatePublished - Sep 25 2013

    Fingerprint

Keywords

  • Biochemical mediators
  • Cartilage
  • Osteoarthritic pain
  • Osteoarthritis

ASJC Scopus subject areas

  • Genetics

Cite this

Lee, A. S., Ellman, M. B., Yan, D., Kroin, J. S., Cole, B. J., van Wijnen, A. J., & Im, H. J. (2013). A current review of molecular mechanisms regarding osteoarthritis and pain. Gene, 527(2), 440-447. https://doi.org/10.1016/j.gene.2013.05.069