TY - JOUR
T1 - A cortical (V1) neurophysiological recording model for assessing the efficacy of retinal visual prostheses
AU - Elfar, Sylvia D.
AU - Cottaris, Nicolas P.
AU - Iezzi, Raymond
AU - Abrams, Gary W.
N1 - Funding Information:
The authors are grateful to Tauseef Raza for stimulator hardware manufacture and electronics support, and Tiffany Walraven Kent and Inna Glybina for their assistance during surgeries and experiments. This work was supported by the Ligon Research Center of Vision and by an unrestricted grant from Research to Prevent Blindness to the Department of Ophthalmology, Kresge Eye Institute at Wayne State University.
PY - 2009/6/15
Y1 - 2009/6/15
N2 - A significant barrier to the development of a retinal prosthesis that is capable of inducing spatially patterned visual percepts has been a lack of adequate models to assess the efficacy of various electrical stimulation algorithms. Toward this end, we developed an in vivo, normally sighted animal model that is based on primary visual cortex neurophysiological recordings of spiking and local-field potential activity. Here, we describe this model, and we present results related to the spatial spread and location of the induced retinal activation. Our findings demonstrate that a single epiretinally delivered electric pulse induces two temporally separated cortical responses whose latencies are similar to the previously reported double responses of retinal ganglion cells (RGCs). Furthermore, our model indicates that the short latency response originates in widespread retinal locations that extend well beyond the location of the activated electrodes, whereas the long latency response has a more focal origin which corresponds to the location of the activated electrodes. The present work demonstrates the applicability of our model for the evaluation and development of electrical retinal stimulation methods using cortical recordings.
AB - A significant barrier to the development of a retinal prosthesis that is capable of inducing spatially patterned visual percepts has been a lack of adequate models to assess the efficacy of various electrical stimulation algorithms. Toward this end, we developed an in vivo, normally sighted animal model that is based on primary visual cortex neurophysiological recordings of spiking and local-field potential activity. Here, we describe this model, and we present results related to the spatial spread and location of the induced retinal activation. Our findings demonstrate that a single epiretinally delivered electric pulse induces two temporally separated cortical responses whose latencies are similar to the previously reported double responses of retinal ganglion cells (RGCs). Furthermore, our model indicates that the short latency response originates in widespread retinal locations that extend well beyond the location of the activated electrodes, whereas the long latency response has a more focal origin which corresponds to the location of the activated electrodes. The present work demonstrates the applicability of our model for the evaluation and development of electrical retinal stimulation methods using cortical recordings.
KW - Electrical stimulation
KW - Local-field potential activity
KW - Phosphene
KW - Prosthesis
KW - Retinal
KW - Spike activity
KW - Visual cortex
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U2 - 10.1016/j.jneumeth.2009.02.019
DO - 10.1016/j.jneumeth.2009.02.019
M3 - Article
C2 - 19464512
AN - SCOPUS:67349173547
SN - 0165-0270
VL - 180
SP - 195
EP - 207
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 2
ER -