A cortical (V1) neurophysiological recording model for assessing the efficacy of retinal visual prostheses

Sylvia D. Elfar, Nicolas P. Cottaris, Raymond Iezzi, Gary W. Abrams

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A significant barrier to the development of a retinal prosthesis that is capable of inducing spatially patterned visual percepts has been a lack of adequate models to assess the efficacy of various electrical stimulation algorithms. Toward this end, we developed an in vivo, normally sighted animal model that is based on primary visual cortex neurophysiological recordings of spiking and local-field potential activity. Here, we describe this model, and we present results related to the spatial spread and location of the induced retinal activation. Our findings demonstrate that a single epiretinally delivered electric pulse induces two temporally separated cortical responses whose latencies are similar to the previously reported double responses of retinal ganglion cells (RGCs). Furthermore, our model indicates that the short latency response originates in widespread retinal locations that extend well beyond the location of the activated electrodes, whereas the long latency response has a more focal origin which corresponds to the location of the activated electrodes. The present work demonstrates the applicability of our model for the evaluation and development of electrical retinal stimulation methods using cortical recordings.

Original languageEnglish (US)
Pages (from-to)195-207
Number of pages13
JournalJournal of Neuroscience Methods
Volume180
Issue number2
DOIs
StatePublished - Jun 15 2009
Externally publishedYes

Fingerprint

Visual Prosthesis
Reaction Time
Electric Stimulation
Electrodes
Retinal Ganglion Cells
Visual Cortex
Animal Models

Keywords

  • Electrical stimulation
  • Local-field potential activity
  • Phosphene
  • Prosthesis
  • Retinal
  • Spike activity
  • Visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A cortical (V1) neurophysiological recording model for assessing the efficacy of retinal visual prostheses. / Elfar, Sylvia D.; Cottaris, Nicolas P.; Iezzi, Raymond; Abrams, Gary W.

In: Journal of Neuroscience Methods, Vol. 180, No. 2, 15.06.2009, p. 195-207.

Research output: Contribution to journalArticle

Elfar, Sylvia D. ; Cottaris, Nicolas P. ; Iezzi, Raymond ; Abrams, Gary W. / A cortical (V1) neurophysiological recording model for assessing the efficacy of retinal visual prostheses. In: Journal of Neuroscience Methods. 2009 ; Vol. 180, No. 2. pp. 195-207.
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