A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis

Charles Lawrence Loprinzi, S. G. Cianflone, A. M. Dose, P. S. Etzell, N. L. Burnham, Terry M Therneau, L. Hagen, D. K. Gainey, M. Cross, L. M. Athmann, T. Fischer, M. J. O'Connell

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Abstract

Pursuant to a promising report suggesting that an allopurinol mouthwash could have a protective effect against 5-fluorouracil (5-FU)-induced stomatitis, the authors performed a randomized, placebo-controlled, double-blind, crossover study. Seventy-seven patients, receiving their first 5-day course of chemotherapy with 5-FU ± leucovorin, were assigned to use a mouthwash containing 20 mg of allopurinol or a placebo. The mouthwash was administered every hour for four doses commencing with each chemotherapy dose. The severity of subsequent mucositis was graded (on a 0-4 scale) by the attending physician and also by a patient-completed questionnaire. There was trend toward less mucositis in the placebo group with mean physician-judged mucositis scores of 1.3 for placebo and 1.8 for allopurinol (P = 0.07) and mean patient-judged mucositis scores of 1.5 for placebo and 1.9 for allopurinol (P = 0.15). There were no substantial differences in mucositis attributable to the two mouthwashes in the patients who crossed-over on their second cycle of chemotherapy. These data demonstrate that the tested allopurinol mouthwash regimen does not offer any protective effect against 5-FU-induced mucositis.

Original languageEnglish (US)
Pages (from-to)1879-1882
Number of pages4
JournalCancer
Volume65
Issue number8
StatePublished - 1990

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Mouthwashes
Stomatitis
Mucositis
Allopurinol
Fluorouracil
Placebos
Drug Therapy
Physicians
Leucovorin
Double-Blind Method
Cross-Over Studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Loprinzi, C. L., Cianflone, S. G., Dose, A. M., Etzell, P. S., Burnham, N. L., Therneau, T. M., ... O'Connell, M. J. (1990). A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis. Cancer, 65(8), 1879-1882.

A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis. / Loprinzi, Charles Lawrence; Cianflone, S. G.; Dose, A. M.; Etzell, P. S.; Burnham, N. L.; Therneau, Terry M; Hagen, L.; Gainey, D. K.; Cross, M.; Athmann, L. M.; Fischer, T.; O'Connell, M. J.

In: Cancer, Vol. 65, No. 8, 1990, p. 1879-1882.

Research output: Contribution to journalArticle

Loprinzi, CL, Cianflone, SG, Dose, AM, Etzell, PS, Burnham, NL, Therneau, TM, Hagen, L, Gainey, DK, Cross, M, Athmann, LM, Fischer, T & O'Connell, MJ 1990, 'A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis', Cancer, vol. 65, no. 8, pp. 1879-1882.
Loprinzi, Charles Lawrence ; Cianflone, S. G. ; Dose, A. M. ; Etzell, P. S. ; Burnham, N. L. ; Therneau, Terry M ; Hagen, L. ; Gainey, D. K. ; Cross, M. ; Athmann, L. M. ; Fischer, T. ; O'Connell, M. J. / A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis. In: Cancer. 1990 ; Vol. 65, No. 8. pp. 1879-1882.
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