A comparison of images generated from diffusion-weighted and diffusion-tensor imaging data in hyper-acute stroke

Ashley D. Harris, Raoul S. Pereira, Joseph Ross Mitchell, Michael D. Hill, Robert J. Sevick, Richard Frayne

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To compare isotropic (combined diffusion-weighted image [CMB], apparent diffusion coefficient [ADC], TRACE, exponential ADC [eADC], and isotropically-weighted diffusion image [isoDWI]) and anisotropic (relative anisotropy [RA], fractional anisotropy [FA], and volume ratio [VR]) diffusion images collected with fast magnetic resonance (MR) diffusion-weighted (DWI) and diffusion-tensor (DTI) acquisition strategies (each less than one minute) in hyper-acute stroke. Materials and Methods: Twenty-one patients suffering from ischemic stroke-imaged within six hours of symptom onset using both DWI and DTI-were analyzed. Regions of interest were placed in the Ischemic lesion and in normal contralateral tissue and the percent difference in image intensity was calculated for all nine generated images. Results: The average absolute percent changes for the isotropic strategies were all > 38%, with isoDWI found to have a difference of 50.7% ± 7.9% (mean ± standard error, P < 0.001). The ADC maps had the most significant difference (-42.4% ± 2.0%, P < 0.001, coefficient of variation = 0.22). No anisotropic images had significant differences. Conclusion: Anisotropic maps do not consistently show changes in the first six hours of ischemic stroke; therefore, isotropic maps, such as those obtained using DWI, are more appropriate for detecting hyper-acute stroke. Anisotropic images, however, may be useful to differentiate hyper-acute stroke from acute and sub-acute stroke.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume20
Issue number2
DOIs
StatePublished - Aug 2004
Externally publishedYes

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Diffusion Tensor Imaging
Stroke
Anisotropy
Magnetic Resonance Spectroscopy

Keywords

  • Cerebral ischemia
  • Diffusion-tensor imaging
  • Diffusion-weighted imaging
  • Hyper-acute stroke
  • Tissue anisotropy
  • Tissue isotropy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A comparison of images generated from diffusion-weighted and diffusion-tensor imaging data in hyper-acute stroke. / Harris, Ashley D.; Pereira, Raoul S.; Mitchell, Joseph Ross; Hill, Michael D.; Sevick, Robert J.; Frayne, Richard.

In: Journal of Magnetic Resonance Imaging, Vol. 20, No. 2, 08.2004, p. 193-200.

Research output: Contribution to journalArticle

Harris, Ashley D. ; Pereira, Raoul S. ; Mitchell, Joseph Ross ; Hill, Michael D. ; Sevick, Robert J. ; Frayne, Richard. / A comparison of images generated from diffusion-weighted and diffusion-tensor imaging data in hyper-acute stroke. In: Journal of Magnetic Resonance Imaging. 2004 ; Vol. 20, No. 2. pp. 193-200.
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abstract = "Purpose: To compare isotropic (combined diffusion-weighted image [CMB], apparent diffusion coefficient [ADC], TRACE, exponential ADC [eADC], and isotropically-weighted diffusion image [isoDWI]) and anisotropic (relative anisotropy [RA], fractional anisotropy [FA], and volume ratio [VR]) diffusion images collected with fast magnetic resonance (MR) diffusion-weighted (DWI) and diffusion-tensor (DTI) acquisition strategies (each less than one minute) in hyper-acute stroke. Materials and Methods: Twenty-one patients suffering from ischemic stroke-imaged within six hours of symptom onset using both DWI and DTI-were analyzed. Regions of interest were placed in the Ischemic lesion and in normal contralateral tissue and the percent difference in image intensity was calculated for all nine generated images. Results: The average absolute percent changes for the isotropic strategies were all > 38{\%}, with isoDWI found to have a difference of 50.7{\%} ± 7.9{\%} (mean ± standard error, P < 0.001). The ADC maps had the most significant difference (-42.4{\%} ± 2.0{\%}, P < 0.001, coefficient of variation = 0.22). No anisotropic images had significant differences. Conclusion: Anisotropic maps do not consistently show changes in the first six hours of ischemic stroke; therefore, isotropic maps, such as those obtained using DWI, are more appropriate for detecting hyper-acute stroke. Anisotropic images, however, may be useful to differentiate hyper-acute stroke from acute and sub-acute stroke.",
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