A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S1, and pre- S2 particles for revaccination of healthy adult nonresponders

Joseph S. Bertino; Paul Tirrell; Richard N. Greenberg; Harry L. Keyserling; Gregory A. Poland; Dieter Gump; Mary Lou Kumar; Keith Ramsey

doi:10.1093/infdis/175.3.678

A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S₁, and pre- S₂ particles for revaccination of healthy adult nonresponders

Joseph S. Bertino, Paul Tirrell, Richard N. Greenberg, Harry L. Keyserling, Gregory A. Poland, Dieter Gump, Mary Lou Kumar, Keith Ramsey

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The efficacy of 10-μg and 40-μg hepatitis B vaccines was compared with that of an investigational vaccine containing pre-S₁, pre-S₂, and S subunit particles (mixed particle vaccine) in inducing protective anti-hepatitis B surface antigen (anti-HBs) concentrations in 46 otherwise healthy persons who previously did not develop measurable levels of antibodies to at least one complete course of vaccine. A statistically significant difference was seen in the percentage of subjects who developed protective levels of anti-HBs (≤10 mIU/mL) with three 40-μg doses of S subunit vaccine versus the other groups. One hundred percent of the 40-μg dose group developed protective anti-HBs titers. No difference in adverse effects was noted.

Original language	English (US)
Pages (from-to)	678-681
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	175
Issue number	3
DOIs	https://doi.org/10.1093/infdis/175.3.678
State	Published - 1997

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1093/infdis/175.3.678

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Bertino, J. S., Tirrell, P., Greenberg, R. N., Keyserling, H. L., Poland, G. A., Gump, D., Kumar, M. L., & Ramsey, K. (1997). A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S₁, and pre- S₂ particles for revaccination of healthy adult nonresponders. Journal of Infectious Diseases, 175(3), 678-681. https://doi.org/10.1093/infdis/175.3.678

A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S₁, and pre- S₂ particles for revaccination of healthy adult nonresponders. / Bertino, Joseph S.; Tirrell, Paul; Greenberg, Richard N. et al.
In: Journal of Infectious Diseases, Vol. 175, No. 3, 1997, p. 678-681.

Research output: Contribution to journal › Article › peer-review

Bertino, JS, Tirrell, P, Greenberg, RN, Keyserling, HL, Poland, GA, Gump, D, Kumar, ML & Ramsey, K 1997, 'A comparative trial of standard or high-dose S subunit recombinant hepatitis B vaccine versus a vaccine containing S subunit, pre-S₁, and pre- S₂ particles for revaccination of healthy adult nonresponders', Journal of Infectious Diseases, vol. 175, no. 3, pp. 678-681. https://doi.org/10.1093/infdis/175.3.678

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abstract = "The efficacy of 10-μg and 40-μg hepatitis B vaccines was compared with that of an investigational vaccine containing pre-S1, pre-S2, and S subunit particles (mixed particle vaccine) in inducing protective anti-hepatitis B surface antigen (anti-HBs) concentrations in 46 otherwise healthy persons who previously did not develop measurable levels of antibodies to at least one complete course of vaccine. A statistically significant difference was seen in the percentage of subjects who developed protective levels of anti-HBs (≤10 mIU/mL) with three 40-μg doses of S subunit vaccine versus the other groups. One hundred percent of the 40-μg dose group developed protective anti-HBs titers. No difference in adverse effects was noted.",

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