A 3D finite element model of prophylactic vertebroplasty in the metastatic spine

Vertebral stability and stress distribution on adjacent vertebrae

Alessandra Berton, Giuseppe Salvatore, Hugo Giambini, Mauro Ciuffreda, Umile Giuseppe Longo, Vincenzo Denaro, Andrew Thoreson, Kai Nan An

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Objective: Patients with metastatically compromised vertebra can experience pathologic fracture with relevant neurological complications. Vertebroplasty is a low cost procedure and it can potentially prevent neurologic impairment if performed at an early stage. The aim of this study is to evaluate the effects of prophylactic vertebroplasty on stability of the metastatic spine and analyze load distribution at adjacent vertebrae. Setting: A 3D finite element model of two spinal motion segments (L3-L5) was developed. A central core of elements was selected in L4 vertebral body and material properties of a lytic metastasis and successively PMMA were assigned. The model was settled in order to simulate a non-osteoporotic spine and an osteoporotic spine. Outcome Measures: Vertebral stability was assessed by the measurement of vertebral bulge (VB) and vertebral height (VH) on L4. Load transfer on adjacent vertebrae was evaluated by observing the distribution of the von Mises stress on L3 and L5 endplates. Results: The metastasis increased VB by 424% and VH by 626%, while prophylactic vertebroplasty decreased VB and VH by 99% and 95%, respectively, when compared to the normal/non-metastatic model. Prophylactic vertebroplasty increased the average von Mises stress of L3 lower endplate by 1.33% in the non-osteoporotic spine, while it increased to 16% in the osteoporotic model. Conclusions: Prophylactic vertebroplasty could represent an interesting option to improve vertebral strength of metastatically compromised spine without excessively increasing the stresses on adjacent vertebrae in non-osteoporotic spine.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Spinal Cord Medicine
DOIs
StateAccepted/In press - Feb 16 2018

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Vertebroplasty
Spine
Neoplasm Metastasis
Spontaneous Fractures
Polymethyl Methacrylate
Nervous System
Outcome Assessment (Health Care)

Keywords

  • Fracture
  • Metastasis
  • Spine
  • Stability
  • Stress
  • Vertebrae
  • Vertebroplasty

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

A 3D finite element model of prophylactic vertebroplasty in the metastatic spine : Vertebral stability and stress distribution on adjacent vertebrae. / Berton, Alessandra; Salvatore, Giuseppe; Giambini, Hugo; Ciuffreda, Mauro; Longo, Umile Giuseppe; Denaro, Vincenzo; Thoreson, Andrew; An, Kai Nan.

In: Journal of Spinal Cord Medicine, 16.02.2018, p. 1-7.

Research output: Contribution to journalArticle

Berton, Alessandra ; Salvatore, Giuseppe ; Giambini, Hugo ; Ciuffreda, Mauro ; Longo, Umile Giuseppe ; Denaro, Vincenzo ; Thoreson, Andrew ; An, Kai Nan. / A 3D finite element model of prophylactic vertebroplasty in the metastatic spine : Vertebral stability and stress distribution on adjacent vertebrae. In: Journal of Spinal Cord Medicine. 2018 ; pp. 1-7.
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