A 360° electronic device for recording high-resolution intraoperative electrocorticography of the brain during awake craniotomy

Karim ReFaey, Kaisorn L. Chaichana, Anteneh Feyissa, Tito Vivas-Buitrago, Benjamin H. Brinkmann, Erik H. Middlebrooks, Jake H. McKay, David J. Lankford, Shashwat Tripathi, Elird Bojaxhi, Grayson E. Roth, William O. Tatum, Alfredo Quiñones-Hinojosa

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

OBJECTIVE Epilepsy is common among patients with supratentorial brain tumors; approximately 40%–70% of patients with glioma develop brain tumor–related epilepsy (BTRE). Intraoperative localization of the epileptogenic zone during surgical tumor resection (real-time data) may improve intervention techniques in patients with lesional epilepsy, including BTRE. Accurate localization of the epileptogenic signals requires electrodes with high-density spatial organization that must be placed on the cortical surface during surgery. The authors investigated a 360° high-density ring-shaped cortical electrode assembly device, called the “circular grid,” that allows for simultaneous tumor resection and real-time electrophysiology data recording from the brain surface. METHODS The authors collected data from 99 patients who underwent awake craniotomy from January 2008 to December 2018 (29 patients with the circular grid and 70 patients with strip electrodes), of whom 50 patients were matched-pair analyzed (25 patients with the circular grid and 25 patients with strip electrodes). Multiple variables were then retrospectively assessed to determine if utilization of this device provides more accurate real-time data and improves patient outcomes. RESULTS Matched-pair analysis showed higher extent of resection (p = 0.03) and a shorter transient motor recovery period during the hospitalization course (by approximately 6.6 days, p ≤ 0.05) in the circular grid patients. Postoperative versus preoperative Karnofsky Performance Scale (KPS) score difference/drop was greater for the strip electrode patients (p = 0.007). No significant difference in postoperative seizures between the 2 groups was present (p = 0.80). CONCLUSIONS The circular grid is a safe, feasible tool that grants direct access to the cortical surgical surface for tissue resection while simultaneously monitoring electrical activity. Application of the circular grid to different brain pathologies may improve intraoperative epileptogenic detection accuracy and functional outcomes, while decreasing postoperative complications.

Original languageEnglish (US)
Pages (from-to)443-450
Number of pages8
JournalJournal of neurosurgery
Volume133
Issue number2
DOIs
StatePublished - Aug 2020

Keywords

  • Awake craniotomy
  • Brain mapping
  • Circular grid
  • ECoG
  • Electrocorticography
  • Epilepsy
  • Ring-shaped cortical electrode assembly
  • Surgical technique

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    ReFaey, K., Chaichana, K. L., Feyissa, A., Vivas-Buitrago, T., Brinkmann, B. H., Middlebrooks, E. H., McKay, J. H., Lankford, D. J., Tripathi, S., Bojaxhi, E., Roth, G. E., Tatum, W. O., & Quiñones-Hinojosa, A. (2020). A 360° electronic device for recording high-resolution intraoperative electrocorticography of the brain during awake craniotomy. Journal of neurosurgery, 133(2), 443-450. https://doi.org/10.3171/2019.4.JNS19261