230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary

Pedro F. Viana, Jonas Duun-Henriksen, Martin Glasstëter, Matthias Dümpelmann, Ewan S. Nurse, Isabel P. Martins, Sonya B. Dumanis, Andreas Schulze-Bonhage, Dean R. Freestone, Benjamin H. Brinkmann, Mark P. Richardson

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the longest period of subcutaneous EEG (sqEEG) monitoring to date, in a 35-year-old female with refractory epilepsy. Over 230 days, 4791/5520 h of sqEEG were recorded (86%, mean 20.8 [IQR 3.9] hours/day). Using an electronic diary, the patient reported 22 seizures, while automatically-assisted visual sqEEG review detected 32 seizures. There was substantial agreement between days of reported and recorded seizures (Cohen’s kappa 0.664), although multiple clustered seizures remained undocumented. Circular statistics identified significant sqEEG seizure cycles at circadian (24-hour) and multidien (5-day) timescales. Electrographic seizure monitoring and analysis of long-term seizure cycles are possible with this neurophysiological tool.

Original languageEnglish (US)
Pages (from-to)288-293
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume8
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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