230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary

Pedro F. Viana; Jonas Duun-Henriksen; Martin Glasstëter; Matthias Dümpelmann; Ewan S. Nurse; Isabel P. Martins; Sonya B. Dumanis; Andreas Schulze-Bonhage; Dean R. Freestone; Benjamin H. Brinkmann; Mark P. Richardson

doi:10.1002/acn3.51261

230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary

Pedro F. Viana, Jonas Duun-Henriksen, Martin Glasstëter, Matthias Dümpelmann, Ewan S. Nurse, Isabel P. Martins, Sonya B. Dumanis, Andreas Schulze-Bonhage, Dean R. Freestone, Benjamin H. Brinkmann, Mark P. Richardson

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the longest period of subcutaneous EEG (sqEEG) monitoring to date, in a 35-year-old female with refractory epilepsy. Over 230 days, 4791/5520 h of sqEEG were recorded (86%, mean 20.8 [IQR 3.9] hours/day). Using an electronic diary, the patient reported 22 seizures, while automatically-assisted visual sqEEG review detected 32 seizures. There was substantial agreement between days of reported and recorded seizures (Cohen’s kappa 0.664), although multiple clustered seizures remained undocumented. Circular statistics identified significant sqEEG seizure cycles at circadian (24-hour) and multidien (5-day) timescales. Electrographic seizure monitoring and analysis of long-term seizure cycles are possible with this neurophysiological tool.

Original language	English (US)
Pages (from-to)	288-293
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/acn3.51261
State	Published - Jan 2021

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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Viana, P. F., Duun-Henriksen, J., Glasstëter, M., Dümpelmann, M., Nurse, E. S., Martins, I. P., Dumanis, S. B., Schulze-Bonhage, A., Freestone, D. R., Brinkmann, B. H., & Richardson, M. P. (2021). 230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary. Annals of Clinical and Translational Neurology, 8(1), 288-293. https://doi.org/10.1002/acn3.51261

Viana, PF, Duun-Henriksen, J, Glasstëter, M, Dümpelmann, M, Nurse, ES, Martins, IP, Dumanis, SB, Schulze-Bonhage, A, Freestone, DR, Brinkmann, BH & Richardson, MP 2021, '230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary', Annals of Clinical and Translational Neurology, vol. 8, no. 1, pp. 288-293. https://doi.org/10.1002/acn3.51261

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abstract = "We describe the longest period of subcutaneous EEG (sqEEG) monitoring to date, in a 35-year-old female with refractory epilepsy. Over 230 days, 4791/5520 h of sqEEG were recorded (86%, mean 20.8 [IQR 3.9] hours/day). Using an electronic diary, the patient reported 22 seizures, while automatically-assisted visual sqEEG review detected 32 seizures. There was substantial agreement between days of reported and recorded seizures (Cohen{\textquoteright}s kappa 0.664), although multiple clustered seizures remained undocumented. Circular statistics identified significant sqEEG seizure cycles at circadian (24-hour) and multidien (5-day) timescales. Electrographic seizure monitoring and analysis of long-term seizure cycles are possible with this neurophysiological tool.",

author = "Viana, {Pedro F.} and Jonas Duun-Henriksen and Martin Glasst{\"e}ter and Matthias D{\"u}mpelmann and Nurse, {Ewan S.} and Martins, {Isabel P.} and Dumanis, {Sonya B.} and Andreas Schulze-Bonhage and Freestone, {Dean R.} and Brinkmann, {Benjamin H.} and Richardson, {Mark P.}",

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AU - Dümpelmann, Matthias

AU - Nurse, Ewan S.

AU - Martins, Isabel P.

AU - Dumanis, Sonya B.

AU - Schulze-Bonhage, Andreas

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AU - Brinkmann, Benjamin H.

AU - Richardson, Mark P.

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230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary

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