TY - JOUR
T1 - 230 days of ultra long-term subcutaneous EEG
T2 - seizure cycle analysis and comparison to patient diary
AU - Viana, Pedro F.
AU - Duun-Henriksen, Jonas
AU - Glasstëter, Martin
AU - Dümpelmann, Matthias
AU - Nurse, Ewan S.
AU - Martins, Isabel P.
AU - Dumanis, Sonya B.
AU - Schulze-Bonhage, Andreas
AU - Freestone, Dean R.
AU - Brinkmann, Benjamin H.
AU - Richardson, Mark P.
N1 - Funding Information:
This work was supported by the Epilepsy Foundation’s Epilepsy Innovation Institute My Seizure Gauge Project. MPR is supported by the NIHR Biomedical Research Centre; the MRC Centre for Neurodevelopmental Disorders (MR/N026063/1); the EPSRC Centre for Predictive Modelling in Healthcare (EP/N014391/1); the RADAR‐CNS project ( www.radar‐cns.org , grant agreement 115902). We would like to thank Mr. Harutomo Hasegawa and Mr. Richard Selway, Consultant Neurosurgeons from King’s College Hospital NHS Foundation Trust, for performing the implantation procedure.
Publisher Copyright:
© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association
PY - 2021/1
Y1 - 2021/1
N2 - We describe the longest period of subcutaneous EEG (sqEEG) monitoring to date, in a 35-year-old female with refractory epilepsy. Over 230 days, 4791/5520 h of sqEEG were recorded (86%, mean 20.8 [IQR 3.9] hours/day). Using an electronic diary, the patient reported 22 seizures, while automatically-assisted visual sqEEG review detected 32 seizures. There was substantial agreement between days of reported and recorded seizures (Cohen’s kappa 0.664), although multiple clustered seizures remained undocumented. Circular statistics identified significant sqEEG seizure cycles at circadian (24-hour) and multidien (5-day) timescales. Electrographic seizure monitoring and analysis of long-term seizure cycles are possible with this neurophysiological tool.
AB - We describe the longest period of subcutaneous EEG (sqEEG) monitoring to date, in a 35-year-old female with refractory epilepsy. Over 230 days, 4791/5520 h of sqEEG were recorded (86%, mean 20.8 [IQR 3.9] hours/day). Using an electronic diary, the patient reported 22 seizures, while automatically-assisted visual sqEEG review detected 32 seizures. There was substantial agreement between days of reported and recorded seizures (Cohen’s kappa 0.664), although multiple clustered seizures remained undocumented. Circular statistics identified significant sqEEG seizure cycles at circadian (24-hour) and multidien (5-day) timescales. Electrographic seizure monitoring and analysis of long-term seizure cycles are possible with this neurophysiological tool.
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U2 - 10.1002/acn3.51261
DO - 10.1002/acn3.51261
M3 - Article
C2 - 33275838
AN - SCOPUS:85097039358
SN - 2328-9503
VL - 8
SP - 288
EP - 293
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 1
ER -