2003 Wolff award

Possible parasympathetic contributions to peripheral and central sensitization during migraine

David Yarnitsky, Itay Goor-Aryeh, Zahid H. Bajwa, Bernard I. Ransil, F. Michael Cutrer, Anna Sottile, Rami Burstein

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Background. - Neurologic signs of increased parasympathetic outflow to the head often accompany migraine attacks. Because increased parasympathetic outflow to the cranial cavity induces vasodilation of cerebral and meningeal blood vessels, it can enhance plasma protein extravasation and the release of proinflammatory mediators that activate perivascular nociceptors. We recently showed that activation of intracranial perivascular nociceptors induces peripheral and central sensitization along the trigeminovascular pathway and proposed that these sensitizations mediate the intracranial hypersensitivity and the cutaneous allodynia of migraine. Methods. - The present study investigates possible parasympathetic contributions to the generation of peripheral and central sensitization during migraine by applying intranasal lidocaine to reduce cranial parasympathetic outflow through the sphenopalatine ganglion. Results. - In the absence of migraine, patients were pain-free, and their skin sensitivity was normal. Their mean baseline pain thresholds were less than 15°C for cold, more than 45°C for heat, and more than 100 g for mechanical pressure. Their mean pain score was 7.5 of 10 (standard deviation, 1.4) during untreated migraine and 3.5 of 10 (standard deviation, 2.4) after the nasal lidocaine-induced sphenopalatine ganglion block (P < .0001). Most patients developed cutaneous allodynia during migraine, and their mean pain thresholds changed to more than 25°C for cold, less than 40°C for heat, and less than 10 g for mechanical pressure. Following the nasal lidocaine administration (sphenopalatine ganglion block), this allodynia remained unchanged in spite of the pain relief. Conclusion. - These findings suggest that cranial parasympathetic outflow contributes to migraine pain by activating or sensitizing (or both) intracranial nociceptors, and that these events induce parasympathetically independent allodynia by sensitizing the central nociceptive neurons in the spinal trigeminal nucleus.

Original languageEnglish (US)
Pages (from-to)704-714
Number of pages11
JournalHeadache
Volume43
Issue number7
DOIs
StatePublished - Jul 2003
Externally publishedYes

Fingerprint

Central Nervous System Sensitization
Migraine Disorders
Nociceptors
Hyperalgesia
Sphenopalatine Ganglion Block
Lidocaine
Pain Threshold
Pain
Skin
Hot Temperature
Spinal Trigeminal Nucleus
Pressure
Intranasal Administration
Neurologic Manifestations
Nose
Vasodilation
Ganglia
Blood Vessels
Blood Proteins
Hypersensitivity

Keywords

  • Allodynia
  • Headache
  • Migraine
  • Nociceptors
  • Pain
  • Sphenopalatine ganglion
  • Trigeminal

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Yarnitsky, D., Goor-Aryeh, I., Bajwa, Z. H., Ransil, B. I., Cutrer, F. M., Sottile, A., & Burstein, R. (2003). 2003 Wolff award: Possible parasympathetic contributions to peripheral and central sensitization during migraine. Headache, 43(7), 704-714. https://doi.org/10.1046/j.1526-4610.2003.03127.x

2003 Wolff award : Possible parasympathetic contributions to peripheral and central sensitization during migraine. / Yarnitsky, David; Goor-Aryeh, Itay; Bajwa, Zahid H.; Ransil, Bernard I.; Cutrer, F. Michael; Sottile, Anna; Burstein, Rami.

In: Headache, Vol. 43, No. 7, 07.2003, p. 704-714.

Research output: Contribution to journalArticle

Yarnitsky, D, Goor-Aryeh, I, Bajwa, ZH, Ransil, BI, Cutrer, FM, Sottile, A & Burstein, R 2003, '2003 Wolff award: Possible parasympathetic contributions to peripheral and central sensitization during migraine', Headache, vol. 43, no. 7, pp. 704-714. https://doi.org/10.1046/j.1526-4610.2003.03127.x
Yarnitsky, David ; Goor-Aryeh, Itay ; Bajwa, Zahid H. ; Ransil, Bernard I. ; Cutrer, F. Michael ; Sottile, Anna ; Burstein, Rami. / 2003 Wolff award : Possible parasympathetic contributions to peripheral and central sensitization during migraine. In: Headache. 2003 ; Vol. 43, No. 7. pp. 704-714.
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AU - Ransil, Bernard I.

AU - Cutrer, F. Michael

AU - Sottile, Anna

AU - Burstein, Rami

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AB - Background. - Neurologic signs of increased parasympathetic outflow to the head often accompany migraine attacks. Because increased parasympathetic outflow to the cranial cavity induces vasodilation of cerebral and meningeal blood vessels, it can enhance plasma protein extravasation and the release of proinflammatory mediators that activate perivascular nociceptors. We recently showed that activation of intracranial perivascular nociceptors induces peripheral and central sensitization along the trigeminovascular pathway and proposed that these sensitizations mediate the intracranial hypersensitivity and the cutaneous allodynia of migraine. Methods. - The present study investigates possible parasympathetic contributions to the generation of peripheral and central sensitization during migraine by applying intranasal lidocaine to reduce cranial parasympathetic outflow through the sphenopalatine ganglion. Results. - In the absence of migraine, patients were pain-free, and their skin sensitivity was normal. Their mean baseline pain thresholds were less than 15°C for cold, more than 45°C for heat, and more than 100 g for mechanical pressure. Their mean pain score was 7.5 of 10 (standard deviation, 1.4) during untreated migraine and 3.5 of 10 (standard deviation, 2.4) after the nasal lidocaine-induced sphenopalatine ganglion block (P < .0001). Most patients developed cutaneous allodynia during migraine, and their mean pain thresholds changed to more than 25°C for cold, less than 40°C for heat, and less than 10 g for mechanical pressure. Following the nasal lidocaine administration (sphenopalatine ganglion block), this allodynia remained unchanged in spite of the pain relief. Conclusion. - These findings suggest that cranial parasympathetic outflow contributes to migraine pain by activating or sensitizing (or both) intracranial nociceptors, and that these events induce parasympathetically independent allodynia by sensitizing the central nociceptive neurons in the spinal trigeminal nucleus.

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