18F-Florbetapir and 18F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves

Stephen Broski, Robert J. Spinner, Benjamin M. Howe, Angela Dispenzieri, Geoffrey B. Johnson

Research output: Contribution to journalArticle

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Abstract

We present a case of both F-FDG and F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.

Original languageEnglish (US)
Pages (from-to)e115-e117
JournalClinical Nuclear Medicine
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2016

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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