18F-Florbetapir and 18F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves

Stephen M. Broski; Robert J. Spinner; Benjamin M. Howe; Angela Dispenzieri; Geoffrey B. Johnson

doi:10.1097/RLU.0000000000000947

¹⁸F-Florbetapir and ¹⁸F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves

Stephen M. Broski, Robert J. Spinner, Benjamin M. Howe, Angela Dispenzieri, Geoffrey B. Johnson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We present a case of both ¹⁸F-FDG and ¹⁸F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, ¹⁸F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.

Original language	English (US)
Pages (from-to)	E115-E117
Journal	Clinical nuclear medicine
Volume	41
Issue number	2
DOIs	https://doi.org/10.1097/RLU.0000000000000947
State	Published - Feb 1 2016

Keywords

FDG
PET
amyloidosis
florbetapir
nerve
neuropathy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/RLU.0000000000000947

Cite this

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title = "18F-Florbetapir and 18F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves",

abstract = "We present a case of both 18F-FDG and 18F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, 18F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.",

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AU - Howe, Benjamin M.

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AU - Johnson, Geoffrey B.

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AB - We present a case of both 18F-FDG and 18F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, 18F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.

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