1,25-Dihydroxyvitamin D3 receptors in developing dorsal root ganglia of fetal rats

Julie A. Johnson; Joseph P. Grande; Anthony J. Windebank; Rajiv Kumar

doi:10.1016/0165-3806(95)00204-9

1,25-Dihydroxyvitamin D₃ receptors in developing dorsal root ganglia of fetal rats

Julie A. Johnson, Joseph P. Grande, Anthony J. Windebank, Rajiv Kumar

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We observed immunostaining for the 1,25-dihydroxyvitamin D₃ receptor (VDR) and calbindin-D(28k) in neurons, but not glial cells, of fetal rat dorsal root ganglia (DRG) from days 13 through 21 of gestation. Dispersed cultures of DRG collected from rat fetuses at gestational day 15 also contained epitopes for VDR and calbindin-D(28k) in neurons, but not in glial cells. 1,25-Dihydroxyvitamin D₃, through VDR, may perform significant functions in the development of neuronal cells.

Original language	English (US)
Pages (from-to)	120-124
Number of pages	5
Journal	Developmental Brain Research
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(95)00204-9
State	Published - Mar 29 1996

Keywords

1,25-Dihydroxyvitamin D receptor
Calbindin-D(28k)
Dorsal root ganglia
Fetal
Neuron
Rat

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/0165-3806(95)00204-9

Cite this

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title = "1,25-Dihydroxyvitamin D3 receptors in developing dorsal root ganglia of fetal rats",

abstract = "We observed immunostaining for the 1,25-dihydroxyvitamin D3 receptor (VDR) and calbindin-D(28k) in neurons, but not glial cells, of fetal rat dorsal root ganglia (DRG) from days 13 through 21 of gestation. Dispersed cultures of DRG collected from rat fetuses at gestational day 15 also contained epitopes for VDR and calbindin-D(28k) in neurons, but not in glial cells. 1,25-Dihydroxyvitamin D3, through VDR, may perform significant functions in the development of neuronal cells.",

keywords = "1,25-Dihydroxyvitamin D receptor, Calbindin-D(28k), Dorsal root ganglia, Fetal, Neuron, Rat",

author = "Johnson, {Julie A.} and Grande, {Joseph P.} and Windebank, {Anthony J.} and Rajiv Kumar",

note = "Funding Information: niques, and Jewel Podratz for growing the DRG cultures. Supported by NIH Grants: DK25409 (R.K.), DK42971 (R.K.), Training Grant DK07013 (J.A.J.)",

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AU - Kumar, Rajiv

N1 - Funding Information: niques, and Jewel Podratz for growing the DRG cultures. Supported by NIH Grants: DK25409 (R.K.), DK42971 (R.K.), Training Grant DK07013 (J.A.J.)

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N2 - We observed immunostaining for the 1,25-dihydroxyvitamin D3 receptor (VDR) and calbindin-D(28k) in neurons, but not glial cells, of fetal rat dorsal root ganglia (DRG) from days 13 through 21 of gestation. Dispersed cultures of DRG collected from rat fetuses at gestational day 15 also contained epitopes for VDR and calbindin-D(28k) in neurons, but not in glial cells. 1,25-Dihydroxyvitamin D3, through VDR, may perform significant functions in the development of neuronal cells.

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