1,1′ –Ethylidenebis– [tryptophan] induces pathologic alterations in muscle similar to those observed in the eosinophilia–myalgia syndrome

A. M. Emslie-Smith, A. N. Mayeno, S. Nakano, G. J. Gleich, A. G. Engel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

l,l′-Ethylidenebis[tryptophan] (EBT), a derivative of L- tryptophan (LT), is a trace contaminant in batches of LT implicated by epidemiologic evidence in the pathogenesis of the eosinophilia-myalgia syndrome (EMS). We treated female Lewis rats with EBT or unimplicated LT (4 mg per 100 grams daily) by intraperitoneal injection. No rash or weakness occurred in either group. All three EBT rats had a few necrotic muscle fibers. In two rats, perimysium and fascia were abnormally thickened and infiltrated with lymphocytes, macrophages, and sparse eosinophils; two rats had sparse perineurial inflammatory cells. Rats treated with unimplicated LT showed no abnormality. These findings replicate an important feature of human EMS and support the epidemiologic evidence linking EBT to the pathogenesis of the human disease.

Original languageEnglish (US)
Pages (from-to)2390-2392
Number of pages3
JournalNeurology
Volume44
Issue number12
DOIs
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Clinical Neurology

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