α-Synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy

Wen Lang Lin, Michael W. Delucia, Dennis W. Dickson

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

We examined neuronal and oligodendroglial nuclear inclusions and neurites in the pontine base of multiple system atrophy brains using an antibody to α-synuclein. Immunohistochemistry showed α-synuclein positive inclusions in the nuclei of some neurons and oligodendroglia. Immunoelectron microscopy showed that the labeled inclusions were composed of bundles of tightly packed straight filaments with a diameter of 10-20 nm. The filaments were similar, if not identical, in morphology and immunoreactivity, to those found in the soma of neurons and oligodendrocytes with glial cytoplasmic inclusions. In addition, similar immuno-positive filaments were found in dendrites or unmyelinated axons, but not in myelinated axons. The functional significance of these inclusions in terms of transcriptional and axonal dysfunction is unknown.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalNeuroscience Letters
Volume354
Issue number2
DOIs
StatePublished - Jan 9 2004

Keywords

  • Immunoelectron microscopy
  • Immunohistochemistry
  • Multiple system atrophy
  • Neuronal nuclear inclusions
  • α-Synuclein

ASJC Scopus subject areas

  • Neuroscience(all)

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