Zvonimir S Katusic, MD, PhD

  • 11000 Citations
  • 60 Scopus h-Index
1981 …2020
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Research Output 1981 2019

2019

Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex

Nath, K. A., Garovic, V. D., Grande, J. P., Croatt, A. J., Ackerman, A. W., Farrugia, G., Katusic, Z. S., Belcher, J. D. & Vercellotti, G. M., Sep 1 2019, In : American journal of physiology. Renal physiology. 317, 3, p. F695-F704

Research output: Contribution to journalArticle

Acute Kidney Injury
Ischemia
Heme Oxygenase-1
Heme Oxygenase (Decyclizing)
Kidney

Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid

Austin, S. A. & Katusic, Z. S., Jan 1 2019, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Amyloid
Cerebral Amyloid Angiopathy
Nitric Oxide
Blood Vessels
26 Citations (Scopus)

Vascular dysfunction—The disregarded partner of Alzheimer's disease

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M. & 49 others, Markus, H. S., Salman, R. A., Allan, S. M., Quinn, T. J., Kalaria, R. N., Werring, D. J., Carare, R. O., Touyz, R. M., Williams, S. C. R., Moskowitz, M. A., Katusic, Z. S., Lutz, S. E., Lazarov, O., Minshall, R. D., Rehman, J., Davis, T. P., Wellington, C. L., González, H. M., Yuan, C., Lockhart, S. N., Hughes, T. M., Chen, C. L. H., Sachdev, P., O'Brien, J. T., Skoog, I., Pantoni, L., Gustafson, D. R., Biessels, G. J., Wallin, A., Smith, E. E., Mok, V., Wong, A., Passmore, P., Barkof, F., Muller, M., Breteler, M. M. B., Román, G. C., Hamel, E., Seshadri, S., Gottesman, R. F., van Buchem, M. A., Arvanitakis, Z., Schneider, J. A., Drewes, L. R., Hachinski, V., Finch, C. E., Toga, A. W., Wardlaw, J. M. & Zlokovic, B. V., Jan 1 2019, In : Alzheimer's and Dementia. 15, 1, p. 158-167 10 p.

Research output: Contribution to journalShort survey

Blood Vessels
Alzheimer Disease
Biomarkers
Cerebrovascular Circulation
Brain Diseases

Vascular phenotype of amyloid precursor protein-deficient mice

d'Uscio, L. V. & Katusic, Z. S., Jun 1 2019, In : American journal of physiology. Heart and circulatory physiology. 316, 6, p. H1297-H1308

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Blood Vessels
Phenotype
Endothelium
Acetylcholine
2018

Effects of Brain-Derived Neurotrophic Factor on MicroRNA Expression Profile in Human Endothelial Progenitor Cells

He, T., Sun, R., Li, Y. & Katusic, Z. S., Jun 1 2018, In : Cell Transplantation. 27, 6, p. 1005-1009 5 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Endothelial cells
MicroRNAs
Brain
Endothelial Cells
2 Citations (Scopus)

Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells

Sun, R., He, T., Pan, Y. & Katusic, Z. S., Jan 1 2018, In : Aging. 10, 1, p. 100-114 15 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Angiotensin II
Endothelial Cells
Endothelium
Brain
7 Citations (Scopus)

Role of TLR4 signaling in the nephrotoxicity of Heme and heme proteins

Nath, K. A., Belcher, J. D., Nath, M. C., Grande, J. P., Croatt, A. J., Ackerman, A. W., Katusic, Z. S. & Vercellotti, G. M., Jan 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 5, p. F906-F914

Research output: Contribution to journalArticle

Hemeproteins
Toll-Like Receptor 4
Heme
Acute Kidney Injury
Kidney
3 Citations (Scopus)

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential

Nath, K. A., O'Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L. & Katusic, Z. S., Nov 1 2018, In : American journal of physiology. Renal physiology. 315, 5, p. F1493-F1499

Research output: Contribution to journalArticle

Arteriovenous Fistula
Fistula
Chronic Renal Insufficiency
Dialysis
Phenotype
2017
4 Citations (Scopus)

BH4-mediated enhancement of endothelial nitric oxide synthase activity reduces hyperoxia-induced endothelial damage and preserves vascular integrity in the neonate

Edgar, K. S., Galvin, O. M., Collins, A., Katusic, Z. S. & McDonald, D. M., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 230-241 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Nitric Oxide Synthase Type III
Blood Vessels
Endothelial Cells
Green Fluorescent Proteins
2 Citations (Scopus)
4 Citations (Scopus)

Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries

d’Uscio, L. V., He, T., Santhanam, A. V. & Katusic, Z. S., Jan 1 2017, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Protein Deficiency
Cerebral Arteries
Amyloid beta-Protein Precursor
Amyloid
Endothelium
11 Citations (Scopus)

Expression and processing of amyloid precursor protein in vascular endothelium

D’Uscio, L. V., He, T. & Katusic, Z. S., Jan 1 2017, In : Physiology. 32, 1, p. 20-32 13 p.

Research output: Contribution to journalReview article

Amyloid beta-Protein Precursor
Vascular Endothelium
Endothelial Cells
Cerebral Arteries
Proteins

Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic mice

He, T., Sun, R., Santhanam, A. V. R., d'Uscio, L. V., Lu, T. D. & Katusic, Z. S., Jan 1 2017, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Microvessels
Type 1 Diabetes Mellitus
Hippocampus
Disintegrins
7 Citations (Scopus)

Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels

He, T., Santhanam, A. V. R., Lu, T. D., D'Uscio, L. V. & Katusic, Z. S., Jan 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 1, p. 106-122 17 p.

Research output: Contribution to journalArticle

Disintegrins
Amyloid beta-Protein Precursor
Metalloproteases
Epoprostenol
Microvessels
4 Citations (Scopus)

Role of the endothelial caveolae microdomain in shear stress-mediated coronary vasorelaxation

Lu, T. D., Wang, X. L., Chai, Q., Sun, X., Sieck, G. C., Katusic, Z. S. & Lee, H. C., Jan 1 2017, In : Journal of Biological Chemistry. 292, 46, p. 19013-19023 11 p.

Research output: Contribution to journalArticle

Caveolae
Vasodilation
Shear stress
Endothelial Cells
Endothelial cells
2016
16 Citations (Scopus)
Heme Oxygenase-1
Arteriovenous Fistula
Chronic Renal Insufficiency
Up-Regulation
Viral Genes
18 Citations (Scopus)
Nitric Oxide Synthase Type III
Alzheimer Disease
Phosphorylation
Nitric Oxide
Cyclin-Dependent Kinase 5
14 Citations (Scopus)

Neurovascular protective function of endothelial nitric oxide – recent advances –

Katusic, Z. S. & Austin, S. A., 2016, In : Circulation Journal. 80, 7, p. 1499-1503 5 p.

Research output: Contribution to journalReview article

Nitric Oxide
Nitric Oxide Synthase
Endothelium
Phosphodiesterase Inhibitors
Amyloid beta-Protein Precursor
1 Citation (Scopus)

Predicting the functionality and form of a dialysis fistula

Nath, K. A. & Katusic, Z. S., Dec 1 2016, In : Journal of the American Society of Nephrology. 27, 12, p. 3508-3510 3 p.

Research output: Contribution to journalReview article

Fistula
Dialysis
2015
1 Citation (Scopus)

Characterization of cerebral microvasculature in transgenic mice with endothelium targeted over-expression of GTP-cyclohydrolase i

Santhanam, A. V. R., D'Uscio, L. V. & Katusic, Z. S., Nov 2 2015, In : Brain Research. 1625, p. 198-205 8 p.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Microvessels
Transgenic Mice
Endothelium
Nitric Oxide
9 Citations (Scopus)

Hyperoxia depletes (6R)-5,6,7,8-tetrahydrobiopterin levels in the neonatal retina: Implications for nitric oxide synthase function in retinopathy

Edgar, K. S., Matesanz, N., Gardiner, T. A., Katusic, Z. S. & McDonald, D. M., Jun 1 2015, In : American Journal of Pathology. 185, 6, p. 1769-1782 14 p.

Research output: Contribution to journalArticle

Hyperoxia
Nitric Oxide Synthase
Retina
GTP Cyclohydrolase
Vascular Endothelial Growth Factor A
10 Citations (Scopus)
Heme Oxygenase (Decyclizing)
Heme Oxygenase-1
Up-Regulation
Carotid Arteries
Ligation
9 Citations (Scopus)

Regional heterogeneity of cerebral microvessels and brain susceptibility to oxidative stress

Austin, S. A., Santhanam, A. V. R., D'Uscio, L. V. & Katusic, Z. S., Dec 1 2015, In : PLoS One. 10, 12, e0144062.

Research output: Contribution to journalArticle

Oxidative stress
cerebellum
hippocampus
Microvessels
Brain
12 Citations (Scopus)

Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice

Santhanam, A. V. R., D'Uscio, L. V., He, T., Das, P., Younkin, S. G. & Katusic, Z. S., Sep 1 2015, In : Journal of Neurochemistry. 134, 6, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Biological Availability
Superoxides
Microvessels
PPAR delta
2014
105 Citations (Scopus)

Endothelial nitric oxide: Protector of a healthy mind

Katusic, Z. S. & Austin, S. A., 2014, In : European Heart Journal. 35, 14, p. 888-894 7 p.

Research output: Contribution to journalArticle

Nitric Oxide
Amyloid beta-Protein Precursor
Nitric Oxide Synthase Type III
Aptitude
Microglia
11 Citations (Scopus)

Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling

Santhanam, A. V. I. R., d'Uscio, L. V. & Katusic, Z. S., Nov 1 2014, In : Journal of Neurochemistry. 131, 4, p. 521-529 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Erythropoietin
Microvessels
Biological Availability
Oxidative Stress
4 Citations (Scopus)

Erythropoietin prevents endothelial dysfunction in GTP-cyclohydrolase I-deficient hph1 mice

D'Uscio, L. V., Santhanam, A. V. R. & Katusic, Z. S., Jul 7 2014, In : Journal of Cardiovascular Pharmacology. 64, 6, p. 514-521 8 p.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Erythropoietin
Aorta
Nitric Oxide Synthase Type III
Phenylketonurias
12 Citations (Scopus)

Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene

d'Uscio, L. V., He, T., Santhanam, A. V. R., Tai, L. J., Evans, R. M. & Katusic, Z. S., Apr 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 7

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Endothelium
Blood Vessels
Genes
Aorta
2013
18 Citations (Scopus)

Age sensitizes the kidney to heme protein-induced acute kidney injury

Nath, K. A., Grande, J. P., Farrugia, G., Croatt, A. J., Belcher, J. D., Hebbel, R. P., Vercellotti, G. M. & Katusic, Z. S., 2013, In : American Journal of Physiology - Renal Physiology. 304, 3

Research output: Contribution to journalArticle

Hemeproteins
Acute Kidney Injury
Kidney
Hemoglobins
Messenger RNA
32 Citations (Scopus)

Deficient eNOS Phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size

Li, Q., Atochin, D., Kashiwagi, S., Earle, J., Wang, A., Mandeville, E., Hayakawa, K., D'Uscio, L. V., Lo, E. H., Katusic, Z. S., Sessa, W. & Huang, P. L., Nov 2013, In : Stroke. 44, 11, p. 3183-3188 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Stroke
Phosphorylation
Mutation
Middle Cerebral Artery Infarction
66 Citations (Scopus)

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology

Austin, S. A., Santhanam, A. V., Hinton, D. J., Choi, D. S. & Katusic, Z. S., Dec 2013, In : Journal of Neurochemistry. 127, 5, p. 691-700 10 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Pathology
Alzheimer Disease
Nitric Oxide
Nitric Oxide Synthase Type III
10 Citations (Scopus)

Functioning of an arteriovenous fistula requires heme oxygenase

Kang, L., Grande, J. P., Farrugia, G., Croatt, A. J., Katusic, Z. S. & Nath, K. A., May 8 2013, In : American Journal of Physiology - Renal Physiology. 305, 4

Research output: Contribution to journalArticle

Heme Oxygenase (Decyclizing)
Arteriovenous Fistula
Carotid Arteries
Blood Vessels
heme oxygenase-2
21 Citations (Scopus)

Supplementation of Nitric Oxide Attenuates AβPP and BACE1 Protein in Cerebral Microcirculation of eNOS-Deficient Mice

Austin, S. A., D'uscio, L. V. & Katusic, Z. S., 2013, In : Journal of Alzheimer's Disease. 33, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Microcirculation
Nitric Oxide
Nitric Oxide Synthase Type III
Proteins
2012
20 Citations (Scopus)

Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein

D'Uscio, L. V., Das, P., Santhanam, A. V. R., He, T., Younkin, S. G. & Katusic, Z. S., Dec 1 2012, In : Cardiovascular Research. 96, 3, p. 504-512 9 p.

Research output: Contribution to journalArticle

PPAR delta
Amyloid beta-Protein Precursor
Aorta
Superoxides
Transgenic Mice
118 Citations (Scopus)

Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery

Hayakawa, K., Pham, L. D. D., Katusic, Z. S., Arai, K. & Lo, E. H., May 8 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7505-7510 6 p.

Research output: Contribution to journalArticle

Astrocytes
Stroke
Small Interfering RNA
Conditioned Culture Medium
Brain Ischemia
25 Citations (Scopus)

Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells

He, T. & Katusic, Z. S., May 2012, In : Microvascular Research. 83, 3, p. 366-371 6 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Superoxide Dismutase
Endothelial cells
Antioxidants
Phosphotransferases
18 Citations (Scopus)

Increased production of superoxide anion contributes to dysfunction of the arteriovenous fistula

Tsapenko, M. V., d'Uscio, L. V., Grande, J. P., Croatt, A. J., Hernandez, M. C., Ackerman, A. W., Katusic, Z. S. & Nath, K. A., Dec 15 2012, In : American Journal of Physiology - Renal Physiology. 303, 12

Research output: Contribution to journalArticle

Arteriovenous Fistula
Superoxides
Superoxide Dismutase
Neointima
Cyclooxygenase 1
13 Citations (Scopus)

PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice

Santhanam, A. V. R., D'uscio, L. V., He, T. & Katusic, Z. S., Nov 5 2012, In : Brain Research. 1483, p. 89-95 7 p.

Research output: Contribution to journalArticle

PPAR delta
Nitric Oxide Synthase Type III
Microvessels
Cerebrovascular Circulation
NG-Nitroarginine Methyl Ester
39 Citations (Scopus)

Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β 1 subunit degradation in diabetic mice

Lu, T. D., Chai, Q., Yu, L., D'Uscio, L. V., Katusic, Z. S., He, T. & Lee, H. C., Jul 2012, In : Diabetes. 61, 7, p. 1860-1868 9 p.

Research output: Contribution to journalArticle

F-Box Proteins
Large-Conductance Calcium-Activated Potassium Channels
Blood Vessels
Reactive Oxygen Species
Protein Kinase C
38 Citations (Scopus)

Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice

Santhanam, A. V. R., D'Uscio, L. V., Smith, L. A. & Katusic, Z. S., Sep 2012, In : Journal of Neurochemistry. 122, 6, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type III
Microvessels
Superoxides
GTP Cyclohydrolase
Biological Availability
14 Citations (Scopus)

Vascular effects of prostacyclin: Does activation of PPARδ play a role?

Katusic, Z. S., Santhanam, A. V. & He, T., Oct 2012, In : Trends in Pharmacological Sciences. 33, 10, p. 559-564 6 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Epoprostenol
Blood Vessels
Chemical activation
Epoprostenol Receptors
43 Citations (Scopus)

Vasculature and kidney complications in sickle cell disease

Nath, K. A. & Katusic, Z. S., May 2012, In : Journal of the American Society of Nephrology. 23, 5, p. 781-784 4 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Hemolysis
Phenotype
Kidney
Sickle Hemoglobin
2011
27 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
GTP Cyclohydrolase
Nitric Oxide Synthase
Small Interfering RNA
Phosphorylation
20 Citations (Scopus)

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

Kang, K. T., Sullivan, J. C., Spradley, F. T., d'Uscio, L. V., Katusic, Z. S. & Pollock, J. S., Mar 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 3

Research output: Contribution to journalArticle

Angiotensin II
Antihypertensive Agents
Arteries
Phosphorylation
Therapeutics
16 Citations (Scopus)

Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice

D'Uscio, L. V., Smith, L. A. & Katusic, Z. S., Dec 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 6, p. 2227-2234 8 p.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Nitric Oxide Synthase Type III
Aorta
Arteries
Mesenteric Arteries
56 Citations (Scopus)

MCP-1 contributes to arteriovenous fistula failure

Juncos, J. P., Grande, J. P., Kang, L., Ackerman, A. W., Croatt, A. J., Katusic, Z. S. & Nath, K. A., Jan 2011, In : Journal of the American Society of Nephrology. 22, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

Chemokine CCL2
Arteriovenous Fistula
Chemokines
Fistula
Protein Deficiency
9 Citations (Scopus)

Reduced proliferation of aged human vascular smooth muscle cells-role of oxygen-derived free radicals and BubR1 expression

Guntani, A., Matsumoto, T., Kyuragi, R., Iwasa, K., Onohara, T., Itoh, H., Katusic, Z. S. & Maehara, Y., Sep 2011, In : Journal of Surgical Research. 170, 1, p. 143-149 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Free Radicals
Smooth Muscle Myocytes
Oxygen
Reactive Oxygen Species
16 Citations (Scopus)

Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula

Kang, L., Yamada, S., Hernandez, M. C., Croatt, A. J., Grande, J. P., Juncos, J. P., Vercellotti, G. M., Hebbel, R. P., Katusic, Z. S., Terzic, A. & Nath, K. A., Oct 2011, In : American Journal of Physiology - Renal Physiology. 301, 4

Research output: Contribution to journalArticle

Arteriovenous Fistula
Hemodynamics
Heme Oxygenase-1
Vascular Resistance
Cardiac Output
4 Citations (Scopus)

Selective enhancement of contractions to α1-adrenergic receptor activation in the aorta of mice with sickle cell disease

Juncos, R., Juncos, L., Hebbel, R. P., Vercellotti, G. M., Katusic, Z. S. & Nath, K. A., Feb 2011, In : Journal of Cardiovascular Pharmacology. 57, 2, p. 263-266 4 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Adrenergic Receptors
Aorta
Phenylephrine
Adrenergic Agents
2010
35 Citations (Scopus)

Brain-derived neurotrophic factor stimulates production of prostacyclin in cérébral arteries

Santhanam, A. V. R., Smith, L. A. & Katusic, Z. S., Feb 2010, In : Stroke. 41, 2, p. 350-356 7 p.

Research output: Contribution to journalArticle

Basilar Artery
Brain-Derived Neurotrophic Factor
Epoprostenol
Arteries
Rabbits