• 2880 Citations
  • 25 Scopus h-Index
20002020

Research output per year

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Research Output

  • 2880 Citations
  • 25 Scopus h-Index
  • 40 Article
  • 4 Review article
  • 1 Editorial
2020

Brain metastases from non-small cell lung cancer with EGFR or ALK mutations: A systematic review and meta-analysis of multidisciplinary approaches

Singh, R., Lehrer, E. J., Ko, S., Peterson, J., Lou, Y., Porter, A. B., Kotecha, R., Brown, P. D., Zaorsky, N. G. & Trifiletti, D. M., Mar 2020, In : Radiotherapy and Oncology. 144, p. 165-179 15 p.

Research output: Contribution to journalReview article

1 Scopus citations

Influence of Sociodemographic Factors on Treatment Decisions in Non–Small-Cell Lung Cancer

Duma, N., Idossa, D. W., Durani, U., Frank, R. D., Paludo, J., Westin, G., Lou, Y., Mansfield, A. S., Adjei, A. A., Go, R. S. & Ailawadhi, S., May 2020, In : Clinical lung cancer. 21, 3, p. e115-e129

Research output: Contribution to journalArticle

2019

Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy

Ye, Y., Hu, Q., Chen, H., Liang, K., Yuan, Y., Xiang, Y., Ruan, H., Zhang, Z., Song, A., Zhang, H., Liu, L., Diao, L., Lou, Y., Zhou, B., Wang, L., Zhou, S., Gao, J., Jonasch, E., Lin, S. H., Xia, Y. & 5 others, Lin, C., Yang, L., Mills, G. B., Liang, H. & Han, L., Apr 1 2019, In : Nature Metabolism. 1, 4, p. 431-444 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Correlation between immunohistochemistry and RICTOR fluorescence in situ hybridization amplification in small cell lung carcinoma

Krencz, I., Sebestyen, A., Papay, J., Lou, Y., Lutz, G. F., Majewicz, T. L. & Khoor, A., Nov 2019, In : Human Pathology. 93, p. 74-80 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of age and immune landscape on outcome in HER2-positive breast cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) trials

Chumsri, S., Serie, D. J., Li, Z., Pogue-Geile, K. L., Soyano-Muller, A. E., Mashadi-Hossein, A., Warren, S., Lou, Y., Colon-Otero, G., Knutson, K. L., Perez, E. A., Moreno Aspitia, A. & Thompson, E. A., Jan 1 2019, In : Clinical Cancer Research. 25, 14, p. 4422-4430 9 p.

Research output: Contribution to journalArticle

Hypereosinophilia in a patient with metastatic non-small-cell lung cancer treated with antiprogrammed cell death 1 (anti-PD-1) therapy

Lou, Y., Marin-Acevedo, J. A., Vishnu, P., Manochakian, R., Dholaria, B., Soyano, A., Luo, Y., Zhang, Y. & Knutson, K. L., May 2019, In : Immunotherapy. 11, 7, p. 577-584 8 p.

Research output: Contribution to journalArticle

Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma

Pan, D., Zhou, D., Cai, W., Wu, W., Tan, W. L., Zhou, C. & Lou, Y., Nov 13 2019, In : BMC Immunology. 20, 1, 43.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sex Differences in Tolerability to Anti-Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non-Small Cell Lung Cancer: Are We All Equal?

Duma, N., Abdel-Ghani, A., Yadav, S., Hoversten, K. P., Reed, C. T., Sitek, A. N., Enninga, E. A. L., Paludo, J., Aguilera, J. V., Leventakos, K., Lou, Y., Kottschade, L. A., Dong, H. M., Mansfield, A., Manochakian, R., Adjei, A. & Dronca, R. S., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Cancer immunotherapy beyond immune checkpoint inhibitors

Marin-Acevedo, J. A., Soyano, A. E., Dholaria, B., Knutson, K. L. & Lou, Y., Jan 12 2018, In : Journal of Hematology and Oncology. 11, 1, 8.

Research output: Contribution to journalReview article

58 Scopus citations

Comprehensive characterization of alternative polyadenylation in human cancer

Xiang, Y., Ye, Y., Lou, Y., Yang, Y., Cai, C., Zhang, Z., Mills, T., Chen, N. Y., Kim, Y., Ozguc, F. M., Diao, L., Karmouty-Quintana, H., Xia, Y., Kellems, R. E., Chen, Z., Blackburn, M. R., Yoo, S. H., Shyu, A. B., Mills, G. B. & Han, L., Apr 1 2018, In : Journal of the National Cancer Institute. 110, 4, p. 379-389 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

MHC class II restricted neoantigen peptides predicted by clonal mutation analysis in lung adenocarcinoma patients: Implications on prognostic immunological biomarker and vaccine design

Cai, W., Zhou, D., Wu, W., Tan, W. L., Wang, J., Zhou, C. & Lou, Y., Aug 3 2018, In : BMC Genomics. 19, 1, 582.

Research output: Contribution to journalArticle

4 Scopus citations

Next generation of immune checkpoint therapy in cancer: New developments and challenges

Marin-Acevedo, J. A., Dholaria, B., Soyano, A. E., Knutson, K. L., Chumsri, S. & Lou, Y., Mar 15 2018, In : Journal of Hematology and Oncology. 11, 1, 39.

Research output: Contribution to journalReview article

137 Scopus citations

Peripheral blood biomarkers correlate with outcomes in advanced non-small cell lung Cancer patients treated with anti-PD-1 antibodies

Soyano, A. E., Dholaria, B., Marin-Acevedo, J. A., Diehl, N., Hodge, D., Luo, Y., Manochakian, R., Chumsri, S., Adjei, A., Knutson, K. L. & Lou, Y., Nov 23 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 129.

Research output: Contribution to journalArticle

21 Scopus citations

Post-operative radiation therapy in locally advanced non-small cell lung cancer and the impact of sequential versus concurrent chemotherapy

Waddle, M. R., Ko, S., Johnson, M., Lou, Y., Miller, R. C., Harrell, A. C. & Trifiletti, D., Apr 1 2018, In : Translational Lung Cancer Research. 7, p. S171-S175

Research output: Contribution to journalEditorial

Survival trends among non-small-cell lung cancer patients over a decade: impact of initial therapy at academic centers

Lou, Y., Dholaria, B., Soyano, A., Hodge, D., Cochuyt, J., Manochakian, R., Ko, S. J., Thomas, M., Johnson, M., Patel, N. M., Miller, R. C., Adjei, A. & Ailawadhi, S., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

5 Scopus citations

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

Ye, Y., Xiang, Y., Ozguc, F. M., Kim, Y., Liu, C. J., Park, P. K., Hu, Q., Diao, L., Lou, Y., Lin, C., Guo, A. Y., Zhou, B., Wang, L., Chen, Z., Takahashi, J. S., Mills, G. B., Yoo, S. H. & Han, L., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

29 Scopus citations
2017

Cost-effectiveness of pembrolizumab versus docetaxel for the treatment of previously treated PD-L1 positive advanced NSCLC patients in the United States

Huang, M., Lou, Y., Pellissier, J., Burke, T., Liu, F. X., Xu, R. & Velcheti, V., Feb 1 2017, In : Journal of Medical Economics. 20, 2, p. 140-150 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cost Effectiveness of Pembrolizumab vs. Standard-of-Care Chemotherapy as First-Line Treatment for Metastatic NSCLC that Expresses High Levels of PD-L1 in the United States

Huang, M., Lou, Y., Pellissier, J., Burke, T., Liu, F. X., Xu, R. & Velcheti, V., Aug 1 2017, In : PharmacoEconomics. 35, 8, p. 831-844 14 p.

Research output: Contribution to journalArticle

38 Scopus citations
2016

Emerging therapeutic agents for lung cancer

Dholaria, B., Hammond, W., Shreders, A. & Lou, Y., Dec 9 2016, In : Journal of Hematology and Oncology. 9, 1, 138.

Research output: Contribution to journalReview article

56 Scopus citations

Epithelial-mesenchymal transition is associated with a distinct tumor microenvironment including elevation of inflammatory signals and multiple immune checkpoints in lung adenocarcinoma

Lou, Y., Diao, L., Cuentas, E. R. P., Denning, W. L., Chen, L., Fan, Y. H., Byers, L. A., Wang, J., Papadimitrakopoulou, V. A., Behrens, C., Rodriguez, J. C., Hwu, P., Wistuba, I. I., Heymach, J. V. & Gibbons, D. L., Jul 15 2016, In : Clinical Cancer Research. 22, 14, p. 3630-3642 13 p.

Research output: Contribution to journalArticle

147 Scopus citations

Germline Mutation of T790M and Dual/Multiple EGFR Mutations in Patients with Lung Adenocarcinoma

Lou, Y., Pecot, C. V., Tran, H. T., Devito, V. J., Tang, X. M., Heymach, J. V., Luthra, R., Wistuba, I. I., Zuo, Z. & Tsao, A. S., Mar 1 2016, In : Clinical Lung Cancer. 17, 2, p. e5-e11

Research output: Contribution to journalArticle

13 Scopus citations

Molecular basis of antibody binding to mucin glycopeptides in lung cancer

Qu, J., Yu, H., Li, F., Zhang, C., Trad, A., Brooks, C., Zhang, B., Gong, T., Guo, Z., Li, Y., Ragupathi, G., Lou, Y., Hwu, P., Huang, W. & Zhou, D., Feb 2016, In : International journal of oncology. 48, 2, p. 587-594 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice

Liu, C., Peng, W., Xu, C., Lou, Y., Zhang, M., Wargo, J. A., Chen, J. Q., Li, H. S., Watowich, S. S., Yang, Y., Frederick, D. T., Cooper, Z. A., Mbofung, R. M., Whittington, M., Flaherty, K. T., Woodman, S. E., Davies, M. A., Radvanyi, L. G., Overwijk, W. W., Lizée, G. & 1 others, Hwu, P., Jan 15 2013, In : Clinical Cancer Research. 19, 2, p. 393-403 11 p.

Research output: Contribution to journalArticle

190 Scopus citations

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

Hailemichael, Y., Dai, Z., Jaffarzad, N., Ye, Y., Medina, M. A., Huang, X. F., Dorta-Estremera, S. M., Greeley, N. R., Nitti, G., Peng, W., Liu, C., Lou, Y., Wang, Z., Ma, W., Rabinovich, B., Schluns, K. S., Davis, R. E., Hwu, P. & Overwijk, W. W., Apr 1 2013, In : Nature Medicine. 19, 4, p. 465-472 8 p.

Research output: Contribution to journalArticle

241 Scopus citations
2012

Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo

Liu, C., Lewis, C. M., Lou, Y., Xu, C., Peng, W., Yang, Y., Gelbard, A. H., Lizée, G., Zhou, D., Overwijk, W. W. & Hwu, P., Apr 1 2012, In : Journal of Immunotherapy. 35, 3, p. 276-282 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines

Peng, W., Liu, C., Xu, C., Lou, Y., Chen, J., Yang, Y., Yagita, H., Overwijk, W. W., Lizeé, G., Radvanyi, L. & Hwu, P., Oct 15 2012, In : Cancer research. 72, 20, p. 5209-5218 10 p.

Research output: Contribution to journalArticle

202 Scopus citations
2011

Antitumor activity mediated by CpG: The route of administration is critical

Lou, Y., Liu, C., Lizée, G., Peng, W., Xu, C., Ye, Y., Rabinovich, B. A., Hailemichael, Y., Gelbard, A., Zhou, D., Overwijk, W. W. & Hwu, P., Apr 1 2011, In : Journal of Immunotherapy. 34, 3, p. 279-288 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2010

Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses

Peng, W., Ye, Y., Rabinovich, B. A., Liu, C., Lou, Y., Zhang, M., Whittington, M., Yang, Y., Overwijk, W. W., Lizée, G. & Hwu, P., Nov 15 2010, In : Clinical Cancer Research. 16, 22, p. 5458-5468 11 p.

Research output: Contribution to journalArticle

110 Scopus citations
2009

IFN-α enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity

Sikora, A. G., Jaffarzad, N., Hailemichael, Y., Gelbard, A., Stonier, S. W., Schluns, K. S., Frasca, L., Lou, Y., Liu, C., Andersson, H. A., Hwu, P. & Overwijk, W. W., Jun 15 2009, In : Journal of Immunology. 182, 12, p. 7398-7407 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Vaccine site inflammation potentiates idiotype DNAvaccine-induced therapeutic T cell-, and not B cell-, dependent antilymphoma immunity

Qin, H., Cha, S. C., Neelapu, S. S., Lou, Y., Wei, J., Liu, Y. J. & Kwak, L. W., Nov 5 2009, In : Blood. 114, 19, p. 4142-4149 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice

Liu, C., Lou, Y., Lizée, G., Qin, H., Liu, S., Rabinovich, B., Kim, G. J., Wang, Y. H., Ye, Y., Sikora, A. G., Overwijk, W. W., Liu, Y. J., Wang, G. & Hwu, P., Mar 1 2008, In : Journal of Clinical Investigation. 118, 3, p. 1165-1175 11 p.

Research output: Contribution to journalArticle

203 Scopus citations
2007

IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells

Liu, S., Lizée, G., Lou, Y., Liu, C., Overwijk, W. W., Wang, G. & Hwu, P., Oct 1 2007, In : International Immunology. 19, 10, p. 1213-1221 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Plasmacytoid dendritic cells synergize with myeloid dendritic cells in the induction of antigen-specific antitumor immune responses

Lou, Y., Liu, C., Kim, G. J., Liu, Y. J., Hwu, P. & Wang, G., Feb 1 2007, In : Journal of Immunology. 178, 3, p. 1534-1541 8 p.

Research output: Contribution to journalArticle

Open Access
87 Scopus citations
2006

Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells

Xia, C., Zhou, D., Liu, C., Lou, Y., Yao, Q., Zhang, W. & Wang, P. G., Nov 23 2006, In : Organic Letters. 8, 24, p. 5493-5496 4 p.

Research output: Contribution to journalArticle

13 Scopus citations
2005

Active antitumor immunity elicited by vaccine based on recombinant form of epidermal growth factor receptor

Hu, B., Wei, Y., Tian, L., Zhao, X., Lu, Y., Wu, Y., Yao, B., Liu, J., Niu, T., Wen, Y., He, Q., Su, J., Huang, M., Lou, Y., Luo, Y. & Kan, B., Jan 1 2005, In : Journal of Immunotherapy. 28, 3, p. 236-244 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Combination of low-dose gemcitabine and recombinant quail vascular endothelial growth factor receptor-2 as a vaccine induces synergistic antitumor activities

Hou, J. M., Liu, J. Y., Yang, L., Zhao, X., Tian, L., Ding, Z. Y., Wen, Y. J., Niu, T., Xiao, F., Lou, Y. Y., Tan, G. H., Deng, H. X., Li, J., Yang, J. L., Mao, Y. Q. & Wei, Y. Q., Aug 1 2005, In : Oncology. 69, 1, p. 81-87 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2004

Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo

Lou, Y., Wang, G., Lizée, G., Kim, G. J., Finkelstein, S. E., Feng, C., Restifo, N. P. & Hwu, P., Sep 15 2004, In : Cancer research. 64, 18, p. 6783-6790 8 p.

Research output: Contribution to journalArticle

93 Scopus citations
2003

Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-21

Su, J. M., Wei, Y. Q., Tian, L., Zhao, X., Yang, L., He, Q. M., Wang, Y., Lu, Y., Wu, Y., Liu, F., Liu, J. Y., Yang, J. L., Lou, Y. Y., Hu, B., Niu, T., Wen, Y. J., Xiao, F., Deng, H. X., Li, J. & Kan, B., Feb 1 2003, In : Cancer research. 63, 3, p. 600-607 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Immunotherapy of tumors with vaccine based on quail homologous vascular endothelial growth factor receptor-2

Liu, J. Y., Wei, Y. Q., Yang, L., Zhao, X., Tian, L., Hou, J. M., Niu, T., Liu, F., Jiang, Y., Hu, B., Wu, Y., Su, J. M., Lou, Y. Y., He, Q. M., Wen, Y. J., Yang, J. L., Kan, B., Mao, Y. Q., Luo, F. & Peng, F., Sep 1 2003, In : Blood. 102, 5, p. 1815-1823 9 p.

Research output: Contribution to journalArticle

120 Scopus citations

Inhibition of tumor growth with a vaccine based on xenogeneic homologous fibroblast growth factor receptor-1 in mice

He, Q. M., Wei, Y. Q., Tian, L., Zhao, X., Su, J. M., Yang, L., Lu, Y., Kan, B., Lou, Y. Y., Huang, M. J., Xiao, F., Liu, J. Y., Hu, B., Luo, F., Jiang, Y., Wen, Y. J., Deng, H. X., Li, J., Niu, T. & Yang, J. L., Jun 13 2003, In : Journal of Biological Chemistry. 278, 24, p. 21831-21836 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

In Vivo Antitumor Activity of Interleukin 21 Mediated by Natural Killer Cells

Wang, G., Tschoi, M., Spolski, R., Lou, Y., Ozaki, K., Feng, C., Kim, G., Leonard, W. J. & Hwu, P., Dec 15 2003, In : Cancer research. 63, 24, p. 9016-9022 7 p.

Research output: Contribution to journalArticle

193 Scopus citations
2002

A gene therapy for cancer based on the angiogenesis inhibitor, vasostatin

Xiao, F., Wei, Y., Yang, L., Zhao, X., Tian, L., Ding, Z., Yuan, S., Lou, Y., Liu, F., Wen, Y., Li, J., Deng, H., Kang, B., Mao, Y., Lei, S., He, Q., Su, J., Lu, Y., Niu, T., Hou, J. & 1 others, Huang, M. J., Sep 2002, In : Gene Therapy. 9, 18, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

71 Scopus citations

Immunogene therapy of tumors with a vaccine based on the ligand-binding domain of chicken homologous integrin β3

Lou, Y. Y., Wei, Y. Q., Yang, L., Zhao, X., Tian, L., Lu, Y., Wen, Y. J., Liu, F., Huang, M. J., Kang, B., Xiao, F., Su, J. M., He, Q. M., Xie, X. J., Mao, Y. Q., Lei, S., Liu, J. Y., Lou, F., Zhou, L. Q., Peng, F. & 2 others, Jiang, Y. & Hu, B., Apr 25 2002, In : Immunological Investigations. 31, 1, p. 51-69 19 p.

Research output: Contribution to journalArticle

19 Scopus citations
2001

Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen

Wei, Y. Q., Huang, M. J., Yang, L., Zhao, X., Tian, L., Lu, Y., Shu, J. M., Lu, C. J., Niu, T., Kang, B., Mao, Y. Q., Liu, F., Wen, Y. J., Lei, S., Luo, F., Zhou, L. Q., Peng, F., Jiang, Y., Liu, J. Y., Zhou, H. & 11 others, Wang, Q. R., He, Q. M., Xiao, F., Lou, Y. Y., Xie, X. J., Li, Q., Wu, Y., Ding, Z. Y., Hu, B., Hu, M. & Zhang, W., Sep 25 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 20, p. 11545-11550 6 p.

Research output: Contribution to journalArticle

126 Scopus citations
2000

Immunotherapy of tumors with xenogeneic endothelial cells as a vaccine

Wei, Y. Q., Wang, Q. R., Zhao, X., Yang, L., Tian, L., Lu, Y., Kang, B., Lu, C. J., Huang, M. J., Lou, Y. Y., Xiao, F., He, Q. M., Shu, J. M., Xie, X. J., Mao, Y. Q., Lei, S., Luo, F., Zhou, L. Q., Liu, C. E., Zhou, H. & 6 others, Jiang, Y., Peng, F., Yuan, L. P., Li, Q., Wu, Y. & Liu, J. Y., Nov 2 2000, In : Nature Medicine. 6, 10, p. 1160-1166 7 p.

Research output: Contribution to journalArticle

230 Scopus citations